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[color=rgb(28,40,55)][font=arial][size=4]• Characteristic coarse to finely granular cytoplasm and vesiculated nuclei[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• The pustule-ovoid body of milian (POB) is a distinctive finding present in all cases[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• POB is a large pink granule with a clear halo[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• Striking pseudoepitheliomatous hyperplasia is commonly seen[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• Frankly malignant squamous proliferations with striking atypia or atypical mitotic figures should not be disregarded as squamous cell carcinoma can rarely arise in this hyperplastic milieu[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• Nerineural involvement is common and has no significance[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• Granular histiocytes in reactive processes can mimic GCT as can cells in a variety of tumors[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• Learning to recognize the characteristic granular cytoplasm and the POB can avert this confusion[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• Probably of neural origin, granules are lysosomes containing myelin breakdown products[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• GCT cells are positive for S-100 protein and CD68[/size][/font][/color]
[color=rgb(28,40,55)][font=arial][size=4]• Tongue is a characteristic location[/size][/font][/color]