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First Principles of Dermatopathology

If you have just embarked on a career in dermatopathology/dermatology or are considering doing this in the future, then this is the perfect module to give you an insight into its basic principles. The module consists of short video tutorials recorded by Dr Phillip McKee that offer the ideal platform for future in-depth studies, as well as useful tips.

The videos available in this module are listed below:


Acantholysis implies a separation of the keratinocytes due to damage to the desmosomes (intercellular bridges). It may be inherited e.g. Darier’s and Hailey-Hailey disease or due to antibodies to intercellular antigens e.g. pemphigus vulgaris or pemphigus foliaceus... More

A round, eosinophilic body (composed of keratin filaments) within the epidermis and often superficial dermis occurring in a variety of lichenoid and interface dermatoses. They may occasionally be seen in normal skin... More

Granulomatous dermatitis

A granuloma (pleural: granulomata) is a localized or ill-defined collection of epithelioid histiocytes often accompanied by a mixed inflammatory cell infiltrate consisting of lymphocytes, plasma cells and sometimes aggregates of neutrophils... More
Interface dermatitis

Interface dermatitis refers to a constellation of features including basal cell hydropic degeneration, keratinocyte necrosis (apoptosis), and a superficial perivascular and interstitial lymphohistiocytic inflammatory cell infiltrate... More

Lichenoid and lichenoid tissue reactions

The term lichenoid implies a constealtion of features:
- Hyperkeratosis & hypergranulosis
- Irregular (saw-tooth acanthosis)
- Interface change with cytoid bodies... More
Pityriasiform dermatoses

The term Pityriasis comes from the Greek pityron=bran and is used to refer to diseases characterized by fine branny scales. Pityriasis rosea indicates rose colored scales... More

Psoriasiform dermatoses

Features of Psoriasis:
- Confluent parakeratosis
- Munro microabscesses
- Spongiform pustules of Kogoj... More
Pustular dermatoses

Common causes of Pustular dermatoses:
- Pustular psoriasis
- Reiter’s syndrome
- Superficial pemphigus... More


Spongiosis is derived from the Latin & Greek term spongia and implies intercellular edema of the “spongy” (prickle cell) layer of the epidermis or mucosal squamous epithelia. Initially it results in separation of the keratinocytes making the desmosomes... More

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