![](/Principles_Acantholysis.jpg)
Acantholysis implies a separation of the keratinocytes due to damage to the desmosomes (intercellular bridges). It may be inherited e.g. Darier’s and Hailey-Hailey disease or due to antibodies to intercellular antigens e.g. pemphigus vulgaris or pemphigus foliaceus... More
![](/Principles_Granulomatous.jpg)
A granuloma (pleural: granulomata) is a localized or ill-defined collection of epithelioid histiocytes often accompanied by a mixed inflammatory cell infiltrate consisting of lymphocytes, plasma cells and sometimes aggregates of neutrophils... More
![](/Principles_Interface.jpg)
Interface dermatitis refers to a constellation of features including basal cell hydropic degeneration, keratinocyte necrosis (apoptosis), and a superficial perivascular and interstitial lymphohistiocytic inflammatory cell infiltrate... More
![](/Principles_Lichenoid.jpg)
The term lichenoid implies a constealtion of features:
- Hyperkeratosis & hypergranulosis
- Irregular (saw-tooth acanthosis)
- Interface change with cytoid bodies... More
![](/Principles_Pityriasiform.jpg)
The term Pityriasis comes from the Greek pityron=bran and is used to refer to diseases characterized by fine branny scales. Pityriasis rosea indicates rose colored scales... More
![](/Principles_Psoriasiform.jpg)
Features of Psoriasis:
- Confluent parakeratosis
- Munro microabscesses
- Spongiform pustules of Kogoj... More
![](/Principles_Pustular.jpg)
Common causes of Pustular dermatoses:
- Pustular psoriasis
- Reiter’s syndrome
- Superficial pemphigus... More
![](/Principles_Spongiosis.jpg)
Spongiosis is derived from the Latin & Greek term spongia and implies intercellular edema of the “spongy†(prickle cell) layer of the epidermis or mucosal squamous epithelia. Initially it results in separation of the keratinocytes making the desmosomes... More