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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1642 - 11 October Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)
63 year old woman with red nodule on center chest.

Case Posted by Dr Uma Sundram
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  Report Record
Go to records October 2016

User Feedback


vincenzo polizzi

vincenzo polizzi 185

Posted

Cutaneous B peripheral cells marginal zone lymphoma 

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Nitin Khirwadkar

Nitin Khirwadkar 63

Posted

Agree. Dermal nodule with small, monocytoid cells. 

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Raul Perret

Raul Perret 262

Posted

23 minutes ago, arti bakshi said:

Needs immunos....

agree

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Uma Sundram

Uma Sundram 169

Posted

Super! I think all comments point to the most important differential diagnosis, namely marginal zone lymphoma and chronic lymphocytic leukemia (secondary involvement of skin). The lesional cells are CD79a+CD5+CD43+CD23+, supportive of CLL. Years ago, we published a paper looking at CLL vs MZL and found significant histologic overlap, as well as light chain restriction in both entities. PC MZL does not express CD5, which helps confirm the diagnosis of CLL.

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