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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2958 - 08 November 2021 Posted By: Dr. Mona Abdel-Halim

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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F 4 months,The patient presented with generalized tense blisters that started following the 2- month- vaccination doses with gradual onset and progressive course.


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Richard Logan

Posted

Spongiotic vesicle with eosinophils in a female infant suggests incontinentia pigmenti.  However, the onset is rather late and progressive course not typical.  Therefore alternative diagnoses such as a vaccination reaction must be considered.

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Krishnakumar subramanian

Posted

spongiotic sub epidermal vesicle with eosinophils. description is tense blisters. Post vaccination well syndrome has been reported but presenting as tense blisters is not common. DIF data and also CBC blood counts to see whether any eosinophilia is there. if there is any special arrangement of blisters we can consider bullous dermatosis of childhood. 

 

 

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Meenakshi Batrani

Posted

Subepidermal eosinophil rich blister. LABD, although, is a neutrophilic but rarely can have eosinophils predominance. Also, uncommon but BP can have early infantile/childhood onset. DIF is needed. 

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Anil Patki

Posted

I think that this is vaccination-induced infantile bullous pemphigoid. DIF study is needed for confirmation.

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Cem Leblebici

Posted

On 09/11/2021 at 18:06, Anil Patki said:

I think that this is vaccination-induced infantile bullous pemphigoid. DIF study is needed for confirmation.

I liked. Agree with you. 

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vincenzo

Posted

Found this: Baroero et al. BMC Pediatrics (2017) 17:60 DOI 10.1186/s12887-017-0813-0. 

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Dr. Mona Abdel-Halim

Posted

This was diagnosed as vaccination induced infantile bullous pemphigoid

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