Case Number : CT0026 Adam_Bates

Well done the diagnosis is Epithelioid hemangioendothelioma - CD31 +++


HEMANGIOENDOTELIOMA EPITELIOID, VS EPITHELIOID SARCOMA IHQ ? Vim, AE! AE•3, cd 34, FVIII,


HEMANGIOENDOTELIOMA EPITELIOID, VS EPITHELIOID SARCOMA IHQ ? Vim, AE! AE•3, cd 34, FVIII,


Cutaneous epithelioid angiomatous nodule

cutaneous epithelioid angiomatous nodule (CEAN)


Epithelioid hemangioendothelioma.


This is a very interesting and difficult case, I think it looks like an Epitelioid Angiosarcoma.

An epithelioid tumour with focal vacuoles. The differential includes epitheioid haemagioendothelioma, proximal epithelioid sarcoma and, less likely, carcinoma (primary or metastatic). We would do the following immuno: AE1/AE3, INI1, CD34, p63, S100, Fli1

Anaplastic or pleomorphic Kaposi Sarcoma


An infiltrative tumor, composed of nests and cords of large epithelioid cells with abundant esinophilic cytoplsm, vesicular nuclei, prominent nucleoli, and some nuclear pleomorphism. Some cells appear to have intracytoplasmic lumina with RBC's (3rd image). I think there are few mitoses. Thought of epithelioid hemangioendothelioma. Clinically it may present as multiple papules or nodules..


HIGH GRADE MALIGNANT NEOPLASM WITH A PROMINENT SPINDLE CELL MORPHOLOGY. I FAVOUR A SPINDLE CELL CARCINOMA / SARCOMATOID CARCINOMA. HOWEVER, THERE IS AN EXTENSIVE DIFFERENTIAL WHICH REQUIRES CONSIDERATION: (1) POORLY DIFFERENTIATED SCCA; (2) MELANOMA; (3) EPITHELIOD LEIYOMYOSARCOMA; (4) PLEOMORPHIC KAPOSI'S SARCOMA; (5) ATYPICAL FIBROBATOSIS; (6) METASTASIS. I WOULD LIKE TO PERFORM THE FOLLOWING IMMUNOHISTOCHEMICAL STAINS: CAM 5.2/AE1/3; S100/MITF/MELAN A/HMB45; SMA/MSA/DESMIN; HHV8/CD31; BETA CATENIN. CLINICO-PATHOLOGICAL CORRELATION IS ALSO REQUIRED.