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Building Blocks of Dermatopathology

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Case Number : CT0068 Adam_Bates

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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88 year old man with 2.5 cm erythematous very firm nodule on the left abdomen.


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Adam_Bates

Posted

Granular cell tumor.
 

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Adam_Bates

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Agree with granular cell tumour. Coincidentally, I was reading about tumours with granular cells last week, after seeing an undifferentiated pleomorphic sarcoma with granular cells. I came up with this list: Melanoma, hibernoma, rhabdomyoma, leiomyoma and leiomyosarcoma, dermatofibroma and dermatofibrosarcoma and metastatic histiocytoid carcinoma. If anyone has more to add here, please do so.
 

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Adam_Bates

Posted

Very lovely tumor... Have seen five cases this last year ...
 

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Adam_Bates

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I checked my slide database and reference database with the following results:
Non-neural granular cell tumour; Granular cell BCC; Granular cell trichoblastoma (Battistella, Am J Dermatopathol 2013); case of spindle cell angiosarcoma that Arno Rutten put in the UK Skin EQA educational cases I noted focal granular cell changes; focal granular cell change in a glomangiopericytoma; AFX (very xanthomatous case almost granular cell); congenital granular cell epulis (mouth)

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Adam_Bates

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Dear friends, my apologies for the late post. This is indeed granular cell tumor. The stain is S100 as you probably have already guessed, and the tumor is very strongly positive.
 

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