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Case Number : CT0081 Adam_Bates

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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Female 56 years, ulcerated nodules on the trunk. History of pre existing plaques.
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Adam_Bates

Adam_Bates 47

Posted

Diffuse infiltrate with vague nodular pattern of medium sized or large centroblast-like cells and centrocyte-like cells. Mitosis is frequent. This is a malignant lymphoid neoplasm and the differential diagnosis includes: tumour (transformation) stage of MF AND DLBCL. For initial panel of immuno (CD20, CD3, CD30, BCL2, CD21, CD23, CD30, CD4, CD8, CD7, CD5, CD10 AND BCL6)
 

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Adam_Bates

Adam_Bates 47

Posted

MF, tumour stage.
 

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Adam_Bates

Adam_Bates 47

Posted

Tumour (transformation) stage of MF
 

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Adam_Bates

Adam_Bates 47

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Lymphoma, DD: MF or DLBCL. Requires immuno panel.
 

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Adam_Bates

Adam_Bates 47

Posted

Transformation of mycosis fungoides
 

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Adam_Bates

Adam_Bates 47

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As I have to go out for much of the day, I am posting the answer early. You all did very well. This is indeed a case of tumor stage MF with transformation confirmed with immunohistochemistry for CD30. The population of tumor cells are almost all blast forms. Obviously the history of prior plaques makes life much easier when approaching these images.
 

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