Case Number : Case 24 Posted By: Guest

Marcela Saeb Lima - MSLDermatopato (Mexico City) Wrote:

Necrobiotic xanthogranuloma... lovely!

Submitted on 13/07/2010 22:26
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Phillip McKee - Overseas consultations (USA) Wrote:

Hi Mo, many thanks for your kind words they are much appreciated. You are all far too good. The diagnosis is NXG. Well done and see you tomorow. Phillip

Submitted on 13/07/2010 20:51
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JS - UK () Wrote:

Necrobiotic xanthogranuloma

Submitted on 13/07/2010 18:12
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Mo - (India) Wrote:

I think we have some very smart dermatopathologists on this site; I was unsure about this one and so would go for necrobitoic granuloma dd GA, RN, NL. Dr McKee I have been searching for many sites (such as dermpath india) and the quality of the images is so variable - on this site the quality is perfect, as good as what one sees down the microscope. Thank you for setting this up.

Submitted on 13/07/2010 16:57
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Ana Cristina Ruiz - Universidad CES (Medellín Colombia) Wrote:

I see epithelioid and foamy histiocytes in addition to angulated giant cells. There is a foci of necrobiosis and cholesterol clefts. That's why I think that this case is about necrobiotic xanthogranuloma.

Submitted on 13/07/2010 16:51
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Marwa Fawzi - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Necrobiotic xanthogranuloma

Submitted on 13/07/2010 16:41
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Eman El-Nabarawy - Dermatology Department,Faculty of Medicine, Cairo university. (Egypt.) Wrote:

Extensive inflammatory infiltrate with foamy histiocytes, numerous foreign body giant cells,necrobiosis,cholesterol clefts.Necrobiotic xanthogranuloma. DD: necrobiosis lipoidica diabeticorum.

Submitted on 13/07/2010 16:30
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JS - Trainee (London) Wrote:

Necrobiosis lipoidica versus Necrobiotic xanthogranuloma

Submitted on 13/07/2010 14:42
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Phillip McKee - Overseas consultations (USA) Wrote:

Good morning all. You are all doing very we.. Don't forget to look at Marcels's site today, there is a beautiful case this morning.

Submitted on 13/07/2010 13:40
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Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Can not be epithelioid sarcoma, no atypical epithelioid cells (hyperchromasia, pleomorphism and mitosis). No spindle cells. Besides cholestrol clefts with necrobiosis characterizes NXG.

Submitted on 13/07/2010 11:18
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Richard Carr - Warwick () Wrote:

Agree with comments below (i.e. histiocytic some quite ground glass cells with degeneration and cholesterol clefts IKW the very rare NXG ?paraprotein) but as my paranoia is high and we can't see the whole section or history I would just make sure it is not and epithelioid sarcoma!

Submitted on 13/07/2010 11:05
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Rachel - (Manchester ,UK) Wrote:

I see epitheliod histocytes, necrobiotic collagen, giant cells and cholesterol clefts, so necrobiotic xanthogranuloma top of my list of necrobiotic conditions.

Submitted on 13/07/2010 09:46
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Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

I agree also, cholestrol clefts within a necrobiotic collagen surrounded with histiocytes and giant cells. Necrobiotic xanthogranuloma.

Submitted on 13/07/2010 06:31
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Juan Carlos Garces - Hospital Oncológico / Hospital Luis Vernaza (Guayaquil Ecuador) Wrote:

Totally agree with Rodrigo... Necrobiotic Xanthogranuloma...

Submitted on 13/07/2010 01:06
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Rodrigo Restrepo - UPB (Mdlln, Colombia) Wrote:

Necrobiosis associated with bizzarre giant cells and cholesterol clefts is necrobiotic xanthogranuloma

Submitted on 13/07/2010 00:46
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