Case Number : 88 Posted By: Guest

Iskander Chaudhry - Manchester Royal Infirmary (Manchester, UK) Wrote:

Dear All! No clues today and so you went down the wrong track! The diagnosis is Anaplastic large cell lymphoma. The atypical cells are seen in the inflammatory cell infiltrate behind the giant cell.

Submitted on 11/10/2010 21:35
________________________________________
Eduwiges Martínez-Luna - Hospital Gea González (trainee) (Mexico City) Wrote:

cutaneous Rosai Dorfman, wonderful picture!

Submitted on 11/10/2010 21:26
________________________________________
Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Emperipolisis+ lymphocytes + macrophages +plasma cells = Rasai Dorfman. Emperipolesis + lymphocytes + macrophges = Granulomatous Slack skin.

Submitted on 11/10/2010 16:50
________________________________________
Sasi Attili - Ninewells University Hospital (Dundee, UK) Wrote:

Dear Dr.Mckee. Many Thanks for the extremely useful website and the interesting case. I am still a novice in dermatopathology and am learning a lot from the cases on this site. My first impression was that of a lymphohistiocytic tumour. The emperiopolesis and large abnormal histiocytes I think is in keeping with cutaneous rosai-dorfman disease.

Submitted on 11/10/2010 16:49
________________________________________
Juan Carlos Garcés - Hospital Oncológico / Hospital Luis Vernaza (Guayaquil Ecuador) Wrote:

Good morning.. Agree with Rosai Dorfman

Submitted on 11/10/2010 15:02
________________________________________
Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

My first impression is granulomatous slack skin disease. However, the relatively large number of plasma cells and the presence of histiocytes in the right half of the field also showing emperiopolesis (not only the giant cell) will make Rosai Dorfman disease a more likely possibility. Nice Case!!!!

Submitted on 11/10/2010 14:39
________________________________________
Lushen Pillay - Wits Dermatology, South Africa (South Africa) Wrote:

Also thought of a lymphoma, but on checking with Rosai Dorfman - looks more typical.

Submitted on 11/10/2010 14:05
________________________________________
Marcela Saeb Lima - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mexico City) Wrote:

cutaneous Rosai Dorfman

Submitted on 11/10/2010 12:58
________________________________________
Marwa Fawzi - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

I see a bag filled with lots of markedly enlarged anaplastic cells in the middle of mixed infiltrate of lymphocytes &plasma cells???Are we on the way of lymphoma??Is there any one to give a hand please?

Submitted on 11/10/2010 09:43
________________________________________