Case Number : 89 Posted By: Guest

Iskander Chaudhry - Manchester Royal Infirmary (Manchester, UK) Wrote:

Dear All, the final diagnosis is Reticulohistiocytoma. I think it goes to show that you can not seperate these conditions easily and they can show morphological overlap. The giant cells show the characteristic ground glass appearance described in the textbooks. See you all tomorrow!

Submitted on 13/10/2010 01:27
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mahmood - () Wrote:

jxg

Submitted on 13/10/2010 00:51
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Richard Carr - Warwick (UK) Wrote:

Reticulohistiocytosis or reticulohistiocytoma (nice ground glass slightly red histiocytes)

Submitted on 12/10/2010 19:55
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Favor dermatofibroma.

Submitted on 12/10/2010 16:35
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Iskander Chaudhry - Manchester Royal Infirmary (Manchester, UK) Wrote:

Interesting discussion - you are all in the right ball park, however, I am interested in your preferred diagnosis!

Submitted on 12/10/2010 15:58
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Marcela Saeb Lima - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mexico City) Wrote:

Reticulohistiocytoma

Submitted on 12/10/2010 14:51
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Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

I have been thinking a lot in this section. I can see multinucleated giant cells, histiocytes with esinophilic cytoplasm and spindled cells embeded in a highly esinophilic and collagenous stroma. I am thinking of giant cell tumor of tendon sheath. (Although giant cells are not that much osteoclast like!).

Submitted on 12/10/2010 14:20
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Sasi Attili - Ninewells University Hospital (Dundee, UK) Wrote:

Two large giant cells in the center of the field with a couple of others on the left. Large spindle and oval cells with vesicular nuclei and they appear to be interacting with the coarse collage bundles in the background. Not able to appreciate any abnormal mitoses. Is this a fibrocytic tumour of some description. ? Atypical dermatofibroma?

Submitted on 12/10/2010 12:27
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Lee Ming-SGH - Singapore General Hospital () Wrote:

Hmmm. I'd better load some differentials into the blunderbass. Reticulohistiocytosis and juvenile xanthogranuloma are the differentials.

Submitted on 12/10/2010 11:46
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Lee Ming - Singapore General Hospital (See above) Wrote:

I think this is a foreign-body granuloma.The giant-cell at the bottom looks like it contains some phagocytosed refractile material.

Submitted on 12/10/2010 04:08
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