Case Number : 90 Posted By: Guest

Iskander Chaudhry - Manchester Royal Infirmary (Manchester) Wrote:

Yes! It is an SCC with chronic lymphocytic leukaemia. Well done and see you tomorrow.

Submitted on 13/10/2010 21:13
________________________________________
Richard Carr - Warwick (UK) Wrote:

Shame I was hoping to have suggested this without Iskander's help! A classic exam case of dual pathology.

Submitted on 13/10/2010 19:00
________________________________________
Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Agree with Mona and Irina. SCC with infiltrate of chronic lymphocytic leukemia. Marvellous case.

Submitted on 13/10/2010 16:05
________________________________________
Irina - Domina Sana (Buch) Wrote:

squamous cell carcinoma and dense lymphocytic infiltrate,maybe in a patient with chronic lymphocytic leukemia

Submitted on 13/10/2010 15:44
________________________________________
Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

I think I got it. This is a SCC surrounded by the infiltrate of chronic lymphocytic leukemia/ small lymphocytic lymphoma (B-CLL). This is a common phenomenon with this type of leukemia/lymphoma.

Submitted on 13/10/2010 15:41
________________________________________
Iskander Chaudhry - Manchester Royal Infirmary (Manchester ) Wrote:

This is an interesting case and is not a lymph node but biopsy of skin. There are two pathologies going on - can you delineate them? Iskander

Submitted on 13/10/2010 15:21
________________________________________
Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Nice suggestion Marcela!!

Submitted on 13/10/2010 13:19
________________________________________
Marcela Saeb Lima - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mexico City) Wrote:

Mona, I can agree with you. So another possibility might be metastatic SCC to lymph node.

Submitted on 13/10/2010 13:12
________________________________________
Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Hi Marcela, as much as I know and from my very limited knowledge, the epithelial cells in lymphoepithelioma like carcinoma do not show overt signs of squamous differentiation such as horn pearls or dyskeratotic cells. Am I right?? I ruled out the possibility of lymphoepithelioma like carcinoma here because I can see evidence of keratinization.

Submitted on 13/10/2010 12:52
________________________________________
Marcela Saeb Lima - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mexico City) Wrote:

Lymphoepithelial neoplasm, possible lymphoepithelioma like carcinoma

Submitted on 13/10/2010 12:32
________________________________________
Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Islands of atypical squamous cells showing foci of keratinization surrounded with dense lymphocytic infiltrate. My diagnosis is SCC (mostly inflammatory type). Nice case!!

Submitted on 13/10/2010 06:27
________________________________________
Eman El-Nabarawy - Cairo University (Egypt) Wrote:

SCC.

Submitted on 13/10/2010 05:59
________________________________________
Marwa Fawzi - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

SCC of inflammatory type[dense stromal lymphocytic infiltrate surrounding poorly differentiated squamous nests ] .

Submitted on 13/10/2010 05:45
________________________________________
Eduwiges Martínez-Luna - Hospital Gea González (Trainee) (Mexico City) Wrote:

I can see atypical squamous cell with lymphoid infiltrate. Dx invasive squamous cell carcinoma with strong inflamatory respond

Submitted on 13/10/2010 04:20
________________________________________