Case Number : case 98 Posted By: Guest

Phillip McKee - Overseas consultations (USA) Wrote:

AS most have come to the actual diagnosis (xanthogranuloma) I may as well post the answer now. It is probably best to leave the prefix juvenile out as these leasions can also present in adults. I think that necrobiotic xanthogranuloma is a good differential diagnosis as it would be very easy to photograph an identical field with absent necrobiosis (and angulated) giant cells from an example. Mind you, plasma cells are ofetn very numerous in necrobiotic xanthogranuloma and would be a helpful distinguishing feature. Other differential diagnoses that you could have mentioned include xanthoma disseminatum, generalized eruptive histiocytoma etc. It is now thought that these all belong to a spectrum of disease. Scalloped cell xanthogranuloma, benign cepahalic histiocytosis and progressive nodular histiocytosis also fall into this spectrum.

Submitted on 25/10/2010 19:51
________________________________________
Ruifeng Guo - (Oklahoma, USA) Wrote:

Juvenile Xanthogranuloma,cute touton cells.

Submitted on 25/10/2010 18:47
________________________________________
Juan Carlos Garcés - Hospital Oncológico / Hospital Luis Vernaza (Guayaquil Ecuador) Wrote:

Good morning every one... Juvenile Xanthogranuloma

Submitted on 25/10/2010 17:38
________________________________________
Wayne Grayson - (Johannesburg, South Africa) Wrote:

Juvenile xanthogranuloma.

Submitted on 25/10/2010 17:32
________________________________________
Rodrigo Restrepo - UPB/CES (Mdlln. Col) Wrote:

Juvenile xanthogranuloma

Submitted on 25/10/2010 14:06
________________________________________
Marcela Saeb Lima - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mexico City) Wrote:

Juvenile xanthogranuloma. Great week for everyone!

Submitted on 25/10/2010 12:45
________________________________________
Marcela Saeb Lima - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mexico City) Wrote:

Juvenile xanthogranuloma. Great week for everyone!

Submitted on 25/10/2010 12:45
________________________________________
Marwa Fawzi - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Juvenile xanthogranuloma .

Submitted on 25/10/2010 10:55
________________________________________
Saleem Taibjee - Warwick () Wrote:

Others seem to have already confidently diagnosed JXG based on the Touton-type giant cells, and I accept that is probably most likely. However, not all the giant cells in the image appear to be classical Touton-type, some are more irregular. There also appears to be admixed inflammatory cells, mainly lymphocytes. I might want to see a bit more to ensure this isn't part of a more extensive process such as necrobiotic xanthogranuloma.

Submitted on 25/10/2010 09:40
________________________________________
ANDREW DANCKWERTS - WITS UNIVERSITY, JOHANNESBURG (JOHANNESBURG, RSA) Wrote:

JXG WITH TOUTON GIANT CELLS. NICE CASE!

Submitted on 25/10/2010 07:37
________________________________________
Eman El-Nabarawy - Cairo University (Egypt) Wrote:

JXG.

Submitted on 25/10/2010 07:10
________________________________________
Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Juvenile xanthogranuloma with beautifuuly demonstrated cute touton giant cells!!!

Submitted on 25/10/2010 05:10
________________________________________

Tip: click inside this box to load the editor