Case Number : Case 79 Posted By: Guest

Phillip McKee - Overseas Consultations (Arizona, USA) Wrote:

Dear All, thank you for your contributions and sorry for the slightly late reply! Indeed it is a good example of Langerhans cell histiocytosis. Richard thanks for clarifying the mistaken RS cell!

Submitted on 28/09/2010 21:17
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Marcela Saeb Lima - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mexico City) Wrote:

I am late today. But agree with everyone in Langerhans cell hystiocytosis.

Submitted on 28/09/2010 17:05
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Thanks Dr Carr for this description.It was helpful,

Submitted on 28/09/2010 16:43
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Richard Carr - Warwick (UK) Wrote:

It is a binucleate plasma cell. The nuclei are too small for an RS cell - much larger and amphophilic nucleoli and and more oval nuclei with vesicular chromatin. You can see the peri-nuclear hoff and the purple cytoplasm (amphophilic) of the plasma cells that have a small central dark chromatin dot and the peripheral aggregates of chromatin (like a clock face). It is a nice cell but has no meaning in this case which appears to be a case of LCH. REgards to all, Richard

Submitted on 28/09/2010 16:39
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Lushen Pillay - Wits Dermatology, South Africa (South Africa) Wrote:

Langershans cell Histiocytosis

Submitted on 28/09/2010 15:47
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Marwa Fawzi - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

I am asking about the cell which looks like a reed sternberg cell??as it was eye catching to me .If it just a binucleate cell i will go for esinophilic granuloma [LHC]

Submitted on 28/09/2010 10:59
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Galal Elenany - cairo university (faculty of medicine) Wrote:

LCH

Submitted on 28/09/2010 08:55
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ANDREW DANCKWERTS - WITS UNIVERSITY (JHB, RSA) Wrote:

LANGERHAN'S CELL HISTIOCYTOSIS / EOSINOPHILIC GRANULOMA. WOULD LIKE TO CONFIRM WITH CD1a IMMUNOHISTOCHEMICAL STAIN.

Submitted on 28/09/2010 06:43
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Langerhans cell histiocytosis. Is that cell at the left lower corner owel eyes cell(Reed-Sternberg cell)? Could then add DD of mixes cellularity Hodjkin's Lymphoma? Or its just a multinucleated giant cell in the context of LGH?

Submitted on 28/09/2010 05:45
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Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Large histiocytes, most of them with indented reniform nuclei and lots of esinophils. Esinophilic Granuloma (one of the 3 types of Langerhans Cell Histiocytosis, now known collectively as Langerhans Cell Disease)

Submitted on 28/09/2010 04:10
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Rodrigo Restrepo - UPB/CES (Mdlln/Colombia) Wrote:

Langerhans cell histiocitosis

Submitted on 28/09/2010 02:42
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Juan Carlos Garcés - Hospital Oncológico / Hospital Luis Vernaza (Guayaquil Ecuador) Wrote:

Good evening. Agree with Langerhans cell histiocytosis

Submitted on 28/09/2010 02:07
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Ruifeng Guo - OUHSC (OK,USA) Wrote:

Forgot to mention one thing. Having said that this is is LCG, these atypical changes still bother me. So malignant hisiocytosis should be differetiated, although I have never seen one before.

Submitted on 28/09/2010 01:58
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Ruifeng Guo - OUHSC (OK, USA) Wrote:

It looks so much like eosinophilic granuloma. The presence of atypical mitosis and pleomorphism of the histiocytes may be just reactive. So I agree this is Langerhans cell histiocytosis.

Submitted on 28/09/2010 01:47
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Gonzalo De Toro - Hospital Base Puerto Montt (Chile) Wrote:

Hi everyone, could be Langerhans cell histiocitosis (large cells with some folded and kidney nuclei and eos.

Submitted on 28/09/2010 01:23
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