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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 129 Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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metastasis from a clear cell sarcoma


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Phillip McKee - Overseas consultations (Sedona, Arizona, USA) Wrote:

This is an exceedingly difficult case and it is not really possible to come to a diagnosis on the basis of this one image. I included it to make you all aware of the various morphologies that tumors may have. This is in fact a metastasis from a clear cell sarcoma which Alex Lazar kindly shared with me. Although much of the tumor showed the features as seen in this field, there were areas of clear cell change and focal melanin pigment was present. I can very easily see how some of you thought of a hidradenoma. Phillip

Submitted on 07/12/2010 18:47
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Wayne Grayson - (Johannesburg, South Africa) Wrote:

Tough one... I think I favour an eccrine spiradenoma though.

Submitted on 07/12/2010 17:31
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Juan Carlos Garcés - Hospital Oncológico / Hospital Luis Vernaza (Guayaquil Ecuador) Wrote:

Good morning everyone.. or good afternoon..Benign epithelial tumor, looks like adenexal tumor.. two kind of cells...hilainized stroma... Eccrine spiradenoma?

Submitted on 07/12/2010 15:47
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Thought of malignant cylindroma.

Submitted on 07/12/2010 13:05
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Mona Abdel-Halim - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

I think I am seeing a polymoprphic lymphoid infiltrate, some plasma cells, few esinophils and may be some histiocytes. Admixed with the infiltrate, I think there are capillaries that look hyalinized or surrounded with esinophilic hyaline material. I am thinking of angioimmunoblastic lymphadenopathy. Less likely another case of hyaline vascular variant of Castleman's disease. The other possibility is that I am totally wrong and this might be as Dr Carr said an Esoteric Confusing Odd Mesmerising Entity!!!!!!!!!

Submitted on 07/12/2010 13:03
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Miah Singh - (UK) Wrote:

Great suggestion from Richard. Must remember that entity. I wondered about a funny angiosarcoma.

Submitted on 07/12/2010 11:42
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Richard Carr - Warwick (UK) Wrote:

Like your suggestion. Possibly Esoteric Confusing Odd Mesmerising Entity?

Submitted on 07/12/2010 10:34
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Alistair Kayne - (UK) Wrote:

Hidradenoma although ducts not that visible

Submitted on 07/12/2010 08:05
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