Case Number : Case 282 Posted By: Guest

Iskander Chaudhry - Central Manchester Trust (Manchester, U.K.) Wrote:

This is not an easy case and you are only seeing a few images - it is in fact metastatic colonic carcinoma. The key features are the desmoplastic stromal reaction and cytologically atypical columnar glands.

Submitted on 12/07/2011 03:41
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Marie MD - () Wrote:

metastatic adenoca: GI/panc/biliary

Submitted on 11/07/2011 10:49
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ANDREW DANCKWERTS - NHLS, WITS UNIVERSITY (JOHANNESBURG, RSA) Wrote:

PRIMARY ECCRINE ADENOMA. WHILEST THERE IS A DESMOPLASTIC STROMAL RESPONSE, I AM NOT SURE THIS LESION IS INVASIVE!!! IFIT IS, THEN METASTATIC PAPILLARY ADENOCARCINOMA IS FAVOURED - CK7 / CK20 / TTF1 IMMUNOHISTOCHEMICAL WORK-UP IS REQUIRED.

Submitted on 11/07/2011 05:46
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Juan Carlos Garcés - Hospital Luis Vernaza / Hospital Oncológico (Guayaquil Ecuador) Wrote:

Mestastatic adenocarcinoma

Submitted on 08/07/2011 15:12
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Gonzalo De Toro (CHILE) - () Wrote:

I agree with you Rodrigo: metastatic colorectal cancer. Mucin+desmoplastic stroma+papillary adenocarcinoma

Submitted on 08/07/2011 12:27
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Rathi Ramakrishnan - Imperial College Hospital Trust Hospitals (St Mary's +) Wrote:

Papillary adenocarcinoma with apocrine features. Besides metastatic cancer I would also like to consider primary cutaneous apocrine carcinoma.

Submitted on 08/07/2011 10:55
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Marwa Fawzi - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Metastatic papillary adenocarcinoma

Submitted on 08/07/2011 09:30
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Diana Alvarez - (The Netherlands) Wrote:

Metastatic adenocarcinoma

Submitted on 08/07/2011 08:57
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Richard Carr - Warwick (UK) Wrote:

Also favour metastatic adenocarcinoma upper GIT/pancreatico-hepatobiliary tract first guess but clearly clinical work-up +/- immunostains

Submitted on 08/07/2011 08:47
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Rodrigo Restrepo - UPB/CES (Mdll/Col) Wrote:

Metastatic colorectal cancer

Submitted on 08/07/2011 08:27
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Metastatic papillary adenocarcinoma.

Submitted on 08/07/2011 05:08
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Mona Abdel Halim - Dermatology Department, Faculty of medicine, Cairo University (Egypt) Wrote:

Since the papillary structures are true papillae with fibrovascular cores and the stroma is desmoplastic, I believe this is a papillary adenocarcinoma. Most propably metastatic papillary adenocarcinoma (age and site correlation). Immunihistochemistry to exclude a primary origin is essential.

Submitted on 08/07/2011 04:56
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Hazem Hamed - Department of Histopathology, Imperial College London (LONDON) Wrote:

A fairly circumscribed dermal nodule composed of variably sized and shaped glands lined by single layer of columnar cells with areas of stratification and papillae formation. Some glands show cells with atypical features (image 4). There is no epidermal connection. There is a surrounding desmoplasia with mild patchy lymphocytic host response. The features are suggestive of metastatic papillary adenocarcinoma. Correlation with clinical and radiological findings is essential to exclude any primary. Immunohistochemistry for CK7, CK20 PSA and TTF1 is required. The main DD is papillary eccrine adenoma which I think is unlikely in this case.

Submitted on 08/07/2011 04:44
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