Case Number : Case 269 Posted By: Guest

Phillip McKee - Overseas consultations (Cave, Creek, USA) Wrote:

Well done those of you who made the diagnosis of pleomorphic hyalinizing angiectatic tumor. The 4 images show all the features- angiectatic vessels, spindled cells, some with atypia and focal stromal hyalinization

Submitted on 21/06/2011 14:09
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Mohammad Alqudah - MRI (Manchester-UK) Wrote:

The lesion is composed of solid nests of benign looking spindle cells surrounding blood filled spaces and blood vessels. Inflammatory cells and some multinucleated cells are seen. Location and microscopic features favour Angiomatoid fibrous histiocytoma. Half cases are positive for desmin and CD99

Submitted on 21/06/2011 14:00
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

I'd like to add (Symplastic hemangioma) to my DD Angiomatoid fibrous histiocytoma.

Submitted on 21/06/2011 12:56
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ANDREW DANCKWERTS - NHLS, WITS UNIVERSITY (JOHANNESBURG, RSA) Wrote:

VASOFORMATIVE MESENCHYMAL NEOPLASM. I FAVOUR ANGIOMATOID FIBROUS HISTIOCYTOMA (AFH); HOWEVER, I CANNOT ENTIRELY EXCLUDE KAPOSI SARCOMA. ONE WOULD NEED IMMUNOHISTOCHEMICAL STAINS TO DIFFERENTIATE BETWEEN THESE ENTITIES.

Submitted on 21/06/2011 12:15
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Juan Carlos Garcés - Hospital Oncológico / Hospital Luis Vernaza (Guayaquil Ecuador) Wrote:

Good morning / afternoo to everety body around the world. Pleomorphic hyalinizing angiectatic tumor. DD. Spindle cell hemangioma ( in young adults )

Submitted on 21/06/2011 12:14
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MSMD - (NY) Wrote:

I believe this is Pleomorphic hyalinizing angiectatic tumor.

Submitted on 21/06/2011 09:46
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Mona Abdel Halim - Dermatology Department, Faculty of medicine, Cairo University (Egypt) Wrote:

I have been thinking in this lesion for 2 hurs now!!! Angiomatoid fibrous histiocytoma was my first impression but it is usually a tumor of children and young adults so it does not fit with the age of this case. I searched again and I think this could be PHAT, pleomorphic hyalinizing angiectatic tumor. We have here ectatic fibrin containing vessels, there is also circumferential hyalinization around the vascular spaces, we have short fascicles of spindled cells and hemosiderin, pleomorphic cells are also seen. I think there is also a myxoid spindle cell areas and variable inflammatory cell infiltrate. I am not sure of the presence of intranuclear inclusion in the bizzare cell in the upper right part of the last image...

Submitted on 21/06/2011 08:54
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Angiomatoid fibrous histiocytoma.

Submitted on 21/06/2011 08:25
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Amira Tawdy - Cairo University (Egypt) Wrote:

I think of glomangiopericytoma

Submitted on 21/06/2011 05:29
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