Case Number : Case 247 Posted By: Guest

Phillip McKee - Overseas consultations (Cave Creek, Arizona, USA) Wrote:

This is a case where clinicopathological correlation and immunohistochemistry are essential. The differential diagnoses you have all come to are good. They include pagetoid reticulosis, CD8+ epidermotropic T-cell lymphoma, mycosis fungoides showing marked epidermotropism, an epidermotropic T-cell pseudolymphoma etc. I have seen a couple of epidermotropic Merkel cell carcinomas so that could be within the differential diagnosis. I don't think Ketron Goodman disease exists. It's description antedated the era of immmunohistochemistry and it is most likely to represent an extremely epidermotropic example of MF or a CD8+ epidermotropic T-cell lymphoma. This was a case of pagetoid reticulosis. Have a great weekend.

Submitted on 20/05/2011 14:27
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Pagetoid reticulosis (Woringer Kolopp).DD MF, lymphomatoid drug reaction, primary cutaneous aggressive epidermotropic CD8 +ve T-cell lymphoma.

Submitted on 20/05/2011 09:30
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Francisco Vilchez - Department of Dermatology. Virgen de la Victoria Clinical Universitary Hospital. (Málaga (Spain)) Wrote:

Agree, Pagetoid Reticulosis. Has anybodie ever seen a Kettron-Goodman??

Submitted on 20/05/2011 08:08
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Marcela Saeb Lima - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Mexico City) Wrote:

Pagetoid reticulosis (Woringer-Kolopp) amazing pic! as always... lovely weekend

Submitted on 20/05/2011 06:47
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Graham Reilly - Princess Elizabeth Hospital (Guernsey UK) Wrote:

Epidermal acanthosis with hyperkeratosis and parakeratosis.Lower half of epidermis particularly infiltrated with atypical lymphoid cells.Appearance of pagetoid reticulosis

Submitted on 20/05/2011 06:01
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ANDREW DANCKWERTS - WITS UNIVERSITY, NHLS (JOHANNESBURG, RSA) Wrote:

MYCOSIS FUNGOIDES. DDx: PAGETOID RETICULOSIS (WORINGER-KOLOPP DISEASE).

Submitted on 20/05/2011 05:47
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Marwa Fawzi - Dermatology Department, Faculty of Medicine, Cairo University (Egypt) Wrote:

Marked epidermotropism of atypical cells,so pagetoid reticulosis is the first d.d ,but i would like to add melanoma to the d.d.

Submitted on 20/05/2011 04:17
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Mona Abdel Halim - Dermatology Department, Faculty of medicine, Cairo University (Egypt) Wrote:

Hyperkeratosis, parakeratosis and psoriasiform hyperplasia. Epidermis shows marked epidermotropism with large atypical lymphocytes mainly in the lower third of the epidermis. Some forming clusters (Pautrier microabscesses).. I bet this is Pagetoid reticulosis (Woringer Kolopp).. Lovely!!

Submitted on 20/05/2011 02:01
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