Case Number : Case 250 Posted By: Guest

Phillip McKee - Overseas consultations (Arizona, USA) Wrote:

This is a wonderful case of Signet-ring cell SCC!!! Yes difficult to make a definitive diagnosis on this one image, however, I do like your lateral thinking. See you tomorrow. Please do encourage others to post as this is what makes the site the great success it is.

Submitted on 25/05/2011 15:18
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Amira Tawdy - Cairo University (Egypt) Wrote:

I think the left side of the field shows classic epitheliioid hemangioendothelioma with its characteristic myxoid stroma while the rest of the field represents transition to epitheliod angiosarcoma wth many large atypical cells

Submitted on 25/05/2011 05:54
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Richard Carr - Warwick (UK) Wrote:

Poro- or hidradenocarcinoma.

Submitted on 25/05/2011 02:24
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Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Epithelioid angiosarcoma with clear cell change. DD epithelioid hemangioendothelioma.

Submitted on 25/05/2011 00:33
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Mona Abdel Halim - Dermatology Department, Faculty of medicine, Cairo University (Egypt) Wrote:

I think this is a malignant vascular neoplasm. We have sheets of pleomorphic large epithelioid cells with esinophilic cytoplasm, large vesicular nuclei and prominent nucleoli. There are also many spindled cells. Many intracytoplasmic lumina are seen with some of them containing RBCs. Many cells show typical signet ring cell appearence. I thought of Epithelioid angiosarcoma OR signet ring cell angiosarcoma. The stroma on the left side appears somehow myxoid, this is a feature of the lowgrade malignant vascular neoplasm (epithelioid hemangioendothelioma) but usually the pleomorphism in it is not so marked. However, a subset of epithelioid hemangioendothelioma has been reported with a more aggressive clinical course and showing prominent cytological atypia and high mitosis overlapping histologically with epithelioid angiosarcoma, so it could also be the case....

Submitted on 24/05/2011 17:33
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Phillip McKee - Overseas consultations (Arizona, USA) Wrote:

This is a wonderful case of Signet-ring cell SCC!!! Yes difficult to make a definitive diagnosis on this one image, however, I do like your lateral thinking. See you tomorrow. Please do encourage others to post as this is what makes the site the great success it is.

Submitted on 25/05/2011 15:18
________________________________________
Amira Tawdy - Cairo University (Egypt) Wrote:

I think the left side of the field shows classic epitheliioid hemangioendothelioma with its characteristic myxoid stroma while the rest of the field represents transition to epitheliod angiosarcoma wth many large atypical cells

Submitted on 25/05/2011 05:54
________________________________________
Richard Carr - Warwick (UK) Wrote:

Poro- or hidradenocarcinoma.

Submitted on 25/05/2011 02:24
________________________________________
Eman El-Nabarawy - Cairo University (Egypt) Wrote:

Epithelioid angiosarcoma with clear cell change. DD epithelioid hemangioendothelioma.

Submitted on 25/05/2011 00:33
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Mona Abdel Halim - Dermatology Department, Faculty of medicine, Cairo University (Egypt) Wrote:

I think this is a malignant vascular neoplasm. We have sheets of pleomorphic large epithelioid cells with esinophilic cytoplasm, large vesicular nuclei and prominent nucleoli. There are also many spindled cells. Many intracytoplasmic lumina are seen with some of them containing RBCs. Many cells show typical signet ring cell appearence. I thought of Epithelioid angiosarcoma OR signet ring cell angiosarcoma. The stroma on the left side appears somehow myxoid, this is a feature of the lowgrade malignant vascular neoplasm (epithelioid hemangioendothelioma) but usually the pleomorphism in it is not so marked. However, a subset of epithelioid hemangioendothelioma has been reported with a more aggressive clinical course and showing prominent cytological atypia and high mitosis overlapping histologically with epithelioid angiosarcoma, so it could also be the case....

Submitted on 24/05/2011 17:33
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