Case Number : Case 380 Posted By: Guest

Phillip McKee - Overseas Consultations (Cave Creek, USA) Wrote:

I think that there are curvilinear vessels best seen at low power. This is a case that preceeded the immunohistochemistry era. I think however that it fits best with myxoid MFH but obviously could be wrong!!!!

Submitted on 23/11/2011 11:53
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Mona Abdel Halim - Dermatology Dept. Cairo Univ. (Egypt) Wrote:

Thinking myxofibrosarcoma,,

Submitted on 23/11/2011 11:11
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Zena Slim (SpR Histopath) - () Wrote:

..PS : Another less likely possibility, considering the history of recurrence, is of a myxofibrosarcoma-like DE-DIFFERENTIATED LIPOSARCOMA. But in this location it would be vey unusual - CDK4 and MDM-2 would help if available.

Submitted on 23/11/2011 08:51
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Zena Slim (SpR Histopath) - Wessex Deanery (Queen Alexandra Hospital ) Wrote:

Pleomorphic spindle and polygonal cells in a myxoid stroma and conspicuous 'curvilinear' vessels. I think this is a MYXOFIBROSARCOMA (myxoid MFH). I don't think this is a myxoid liposarcoma or an angiomyxoma as the cells are too pleomorphic and a dermal/subcuticular location would be unusual for a myxoid LPS. I would expect S100 to be negative and CD34 /actins and CD68 to show variable positivity.

Submitted on 23/11/2011 08:47
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A Bansal - BCU HB (North Wales) Wrote:

? myxoid (round cell) liposarcoma. Needs immunos - S100 protein, CD31, CD34, MDM2 etc.

Submitted on 23/11/2011 06:58
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Sasi Attili - (UK) Wrote:

Myxoid tumour with pleomorphic cells and abundant vasculature. Don't see curvilinear vessels but Myxofibrosarcoma (? high grade with the pleomorphic cells).

Submitted on 23/11/2011 06:07
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Hazem Hamed - Department of Histopathology, Imperial College (London) Wrote:

Angiomyxoma

Submitted on 23/11/2011 05:10