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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 573 - 20 Aug Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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Female 32 years with a history of widespread erythematous macules some with a central papule and/or vesicle formation.  Oral lesions were also present.
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Go to records August 2012

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Sasi Attili

Sasi Attili 85

Posted

Early erythema multiforme

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Guest Dr. Francisco Vílchez

Guest Dr. Francisco Vílchez

Posted

Agree, EM.

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Guest
Given the acrosyringeal involvement, could this be drug-related EM (as opposed to herpes-related)?

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Guest
Erythema multiforme (nice interface)

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Guest MarieMD

Guest MarieMD

Posted

diffuse interface dermatitis, c/w EM in the clinical setting noted. However, the parakeratosis seems out of sync w/more acute changes seen, so I will include ddx: drug-induced EM, other drug (including early FDE), early GVHD, early Mucha-habermann

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Dr. Phillip McKee

Dr. Phillip McKee 130

Posted

Well done everyone. This is a nice example of erythema multiforme. The differential diagnosis that Marie has given is good. The absence of any eosinophils makes a drug-related example fairly unlikely although it doesn't exclude it. Graft-versus-host disease can be indistinguishable from the histology shown in this case. Subacute cutaneous lupus erytematosus would be another histological differential diagnosis

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Dr. Phillip McKee

Dr. Phillip McKee 130

Posted

Website news. We are in the process of adding some new features to the site including a module called "Dermatopathology for beginners". This will be in very short video format and will briefly discuss basic terminology such as acantholysis- what it means, what it looks like and what conditions one can see it in.
New modues on specific topics such as nail disease and alopecia are being prepared and there will be more full length lectures on intersting topics such as mycosis fungoides etc. We plan to also have full length mock examinations for those sitting the Boards in Dermatopathology and the Diploma in Dermatopathology.

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Guest Eman El-Nabarawy

Guest Eman El-Nabarawy

Posted

Drug reaction (EM) vs early PLEVA(deep extension of the infiltrate).

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