Case Number : Case 465 Posted By: Guest

[b]Phillip McKee - Overseas Consultations (Cave Creek, Arizona, USA) Wrote:[/b]

Obviously immunohistochemistry is critical although in Fig 4 I tried to illustrate an intracytoplasmic lumen. The tumor expressed vascular makers and is a spindle cell angiosarcoma.

[size=2]Submitted on 23/03/2012 19:33[/size]
[b]Marie MD - () Wrote:[/b]

Malignant, poorly differentiated. Agree with ddx mentioned (SCC, MM, LyoSarc,...) and need for immuno panel

[size=2]Submitted on 22/03/2012 20:47[/size]
[b]Zena Slim (SpR Histopath) - Wessex Deanery () Wrote:[/b]

Spindle cell SCC vs Melanoma . Immuno needed

[size=2]Submitted on 22/03/2012 14:31[/size]
[b]Izzat Abdul-kadir - ST2 - York Hospital (UK) Wrote:[/b]

Spindle-cell SCC.

[size=2]Submitted on 21/03/2012 21:50[/size]
[b]Marcela M. Escanamé - Medical University of Graz (Austria) Wrote:[/b]

Melanoma vs Undifferentiated SCC vs AFX. Immuno mandatory....

[size=2]Submitted on 21/03/2012 21:00[/size]
[b]Richard Carr - Warwick (UK) Wrote:[/b]

We take a much more conservative approach to the AFX/superficial cutaneous sarcoma NOS differential in this clinpath setting i.e. p63 & pan-keratin cocktail (carcinoma); S100 melanoma; CD10 (AFX/cutaneous sarcoma NOS). We only do the others if it looks like a angiosarcoma, leiomyosarcoma, lymphoma etc. That said the chances of something exotic are greatly increased on this site!! Loved the glomeruloid haemangioma. Regards to all.

[size=2]Submitted on 21/03/2012 19:40[/size]
[b]Maria Antonia Pastor - () Wrote:[/b]

Spitzoid melanoma

[size=2]Submitted on 21/03/2012 17:25[/size]
[b]Graham Reilly - PEH (Guernsey) Wrote:[/b]

Malignant spindle cell tumour.I favour Melanoma but I agree requires staining to differentiate from other tumours as mentioned by all.

[size=2]Submitted on 21/03/2012 16:44[/size]
[b]Rodrigo Restrepo - UPB/CES (Mdlln/Col) Wrote:[/b]

Melanoma

[size=2]Submitted on 21/03/2012 16:15[/size]
[b]Omar ErdoÄŸan - () Wrote:[/b]

Leiomyosarcoma.

[size=2]Submitted on 21/03/2012 15:54[/size]
[b]Juan Carlos Garcés - Hospital Oncológico / Hospital Luis Vernaza (Guayaquil Ecuador) Wrote:[/b]

My first thought melanoma

[size=2]Submitted on 21/03/2012 15:24[/size]
[b]ANDREW DANCKWERTS - (JOHANNESBURG, RSA) Wrote:[/b]

HIGH GRADE MALIGNANT NEOPLASM. IN VIEW OF THE AGE AND SITE OF THIS NEOPLASM, THE FOLLOWING DIFFERENTIAL DIAGNOSES REQUIRE CONSIDERATION: (1) LEIYOMYOSARCOMA; (2) SPINDLE CELL MELANOMA; (3) POORLY DIFFERENTIATED SPINDLE CELL CARCINOMA; (4) ANGIOSARCOMA; (5) MERCKEL CELL CARCINOMA; & (6) AFX - BY EXCLUSION. ***************** ONE WOULD REQUIRE AN EXTENSIVE IMMUNOHISTOCHEMICAL STAINING PANEL TO DIFFERENTIATE BETWEEN THESE ENTITIES.

[size=2]Submitted on 21/03/2012 14:44[/size]
[b]Sasi Attili - (United Kingdom) Wrote:[/b]

This is a poorly differentiated tumour. I would do immunos including EMA, CK, S100, CD 34,CD 31, CD 10, LCA, Vimentin, Actin, Desmin

[size=2]Submitted on 21/03/2012 14:26[/size]
[b]Yüksel Okumuş - Bursa State Hospital (Turkey) Wrote:[/b]

Agree with Mona. The other DD : Angiosarcoma

[size=2]Submitted on 21/03/2012 13:56[/size]
[b]Marcela Saeb Lima - INCMNSZ (Mexico City) Wrote:[/b]

Angiosarcoma vs melanoma

[size=2]Submitted on 21/03/2012 13:43[/size]
[b]Eman El-Nabarawy - (Egypt) Wrote:[/b]

Angiosarcoma.

[size=2]Submitted on 21/03/2012 13:39[/size]
[b]Mona Abdel Hali - () Wrote:[/b]

Undifferentiated SCC. Diff diagnosis: melanoma. Immumo is mandatory

[size=2]Submitted on 21/03/2012 13:28[/size]