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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 611 - 11 Oct Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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Female 73 years with multiple tumors and nodules on the right lower leg.
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Go to records October 2012

User Feedback


Sasi Attili

Sasi Attili 85

Posted

looks obviously malignant with the mitoses and pleomorphism. Given the history, these are multiple local mets. Regarding cell lineage (of these plump epithelioid looking cells) I would probably say melanocytic (probably due to the unilaterality of the lesions) vs lymphocytic (anaplastic, but would expect bilateral and more widespread lesions). But one would need a wide immuno panel, including S100, Melan A, HMB 45, LCA, Pan K to start with, and if all negative followed by vimentin, SMA, Desmin, CD 99, EMA etc....

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Guest Dr Wilber J. Martínez

Guest Dr Wilber J. Martínez

Posted

Primary cutaneous diffuse large B-cell lymphoma, leg type

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Guest Guillermo Solis

Guest Guillermo Solis

Posted

Large B cell lymphoma, leg type, vs. metastatic melanoma

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Guest Rodrigo Restrepo

Guest Rodrigo Restrepo

Posted

Diffuse primary large B cell lymphoma of leg type

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Guest MarieMD

Guest MarieMD

Posted

Primary cutaneous large B-cell lymphoma, leg type...Immunos to confirm

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Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

Thought anaplastic large TCL vs. Diffuse large BCL (Leg type).

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Guest hala
I think anaplasitic large cell (CD30+)LYMPHOMA

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Eman El-Nabarawy

Eman El-Nabarawy 69

Posted

Anaplastic large T cell lymphoma.

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Hanan Vaknine MD

Hanan Vaknine MD 18

Posted

The lesion shows slight epidermotropism devoid of a grenz zone.
The cells are anaplastic and very pleomorphic and therefore it is probably not cutaneous DLBCL.
It is most likely Anaplastic Large Cell Lymphoma

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Guest Dr Engin Sezer

Guest Dr Engin Sezer

Posted

Large B cell lymphoma of leg type

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Iskander H. Chaudhry

Iskander H. Chaudhry 49

Posted

Thank you all for your comments! The diagnosis is primary cutaneous diffuse large B-Cell lymphoma.

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