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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 729 - 2 Apr Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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Erythematous scaly patches with hyper- and hypopigmentation on the trunk of a female aged 47 years. Past exposure to gold and aluminum.
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Guest Bansal

Guest Bansal

Posted

? Mycosis fungoides (patch stage). Requires immunohistochemical +/- TCR gene rearrangement studies.

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Sasi Attili

Sasi Attili 85

Posted

MF was my impression too

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Robledo F. Rocha

Robledo F. Rocha 336

Posted

I also favor patch stage of mycosis fungoides.
Epidermotropism of solitary haloed lymphocytes aligned along the basal layer of the epidermis causing disproportionate scant spongiosis. Those intraepidermal lymphocytes exhibit nuclei larger than nuclei of the lymphocytes within superficial dermis.
Compact hyperkeratosis and thickened fibrotic papillary dermis may be signs of persistent scratching.

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Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

Agree, but lymphomatoid drug reaction should also be considered. Sometimes u can not differentiate it from MF neither clinically nor pathologically.

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Dr. Phillip McKee

Dr. Phillip McKee 130

Posted

Well done Mona and Mark. The diagnosis is mycosis fungoides but a drug reaction can be identical. In addition, there are many conditions that may mimic MF including Sezary syndrome and pagetoid reticulosis (excluded by the history), ATLL, CD8+ epidermotropic T-cell lymphoma etc.

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Guest Catarina Shaletich

Guest Catarina Shaletich

Posted

Sugestivo de lesão pouco desenvolvida de MF, a confirmar (correlação clínica, IHQ)

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