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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 689 - 5 Feb Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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31 years-old pregnant female, ulcerated nodule.
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Go to records February 2013

User Feedback


Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

I am not comfortable with this lesion. Cells with spitzoid features are scattered diffusely in the dermis, not nested, S100 positive, so spitzoid melanocytes, I think there is a deep mitosis?? Is this a spitzoid melanoma??

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Sasi Attili

Sasi Attili 85

Posted

agree with Mona. Has to be a melanoma, in a pregnant woman!

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Robledo F. Rocha

Robledo F. Rocha 336

Posted

Amelanotic atypical cells embedded in a markedly fibrotic stroma with patchy lymphocytic infiltrates. Immunohistochemical study shows strong and diffuse S100 staining that extends throughout the full thickness of the dermis, what excludes any evidence of maturation with depth.
Atypical cells are epithelioid with abundant eosinophilic cytoplasm.
I think it’s a desmoplastic melanoma with spitzoid features.

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pathanon
DD: Desmoplastic melanoma, desmoplastic spitz naevus. Favour former.

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Guest Dr Engin Sezer

Guest Dr Engin Sezer

Posted

Desmoplastic melanoma

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Dr. Phillip McKee

Dr. Phillip McKee 130

Posted

This is a mixed spindled cell (Fig 2) and desmoplastic (Fig 3) melanoma. I don't see any spitzoid features.

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