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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 830 - 22nd August Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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7-year-old female, one and a half years post bone marrow transplant for Blackfan Diamond anemia with hyperpigmented plaques with atrophy. The lesion biopsied is from the thigh.

Case posted by Dr. Hafeez Diwan.


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Guest Romualdo

Posted

[font=arial,helvetica,sans-serif][b]Sclerodermatous chronic graft versus host disease.[/b][/font]

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Arti Bakshi

Posted

Dermal scarring, loss of adnexae, pigment incontinence, no active interface change.
c/w late stage of chronic GVHD (sclerodermoid)

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Guest Amira Tawdy

Posted

agree with chronic graft versus host disease

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Robledo F. Rocha

Posted

Sclerodermoid chronic graft-versus-host disease.

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Chronic GVHD - sclerodermoid stage. There´s some interface dermatitis which is also an element of lichenoid stage.

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Guest Rodrigo Restrepo

Posted

Chronic graft versus host disease

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Guest Jim Davie MD

Posted

Given history, a chronic GVHD (sclerodermoid/morpheaform variant) is reasonable.
There are sparse necrotic keratinocytes at the junction with sparse junctional lymphocytes, post-inflammatory hyperpigmentation, relatively normal epidermal architecture, and papillary/reticular dermal sclerosis with encased adnexa (arrector pilus).

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Guest Tiberiu Tebeica

Posted

Chronic GVHD, sclerodermoid phase. Interestingly, pediatric cases of sclerodermoid GVHD are rare!

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