Case Number : Case 813 - 30th July Posted By: Guest

Desmoplastic Trichoepithelioma.

Nice desmoplastic trichoepithelioma.

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In the complete absence of horn cysts and scarcity of elongated epithelial strands I go with a morpheaform basal cell carcinoma.

Desmoplastic trichoepithelioma - central depression seen in first slide.

[color=#1C2837][font=arial, verdana, tahoma, sans-serif][size=4]Desmoplastic Trichoepithelioma[/size][/font][/color]

Desmoplastic BCC

Morpheaform basal cell carcinoma.

DTE

DTE.

[color=#000000][font=Palatino Linotype, serif][size=4]I favor columnar trichoblastoma (desmoplastic trichoepithelioma) over morpheaform basal cell carcinoma:[/size][/font][/color][list]
[*][color=#000000][font=Palatino Linotype, serif][size=4]on scanning magnification, it appears as a symmetric lesion with depressed center;[/size][/font][/color]
[*][color=#000000][font=Palatino Linotype, serif][size=4]cellular fibrous stroma clearly demarcated from surrounding reticular dermis;[/size][/font][/color]
[*][color=#000000][font=Palatino Linotype, serif][size=4]no discernible mitotic figures can be found;[/size][/font][/color]
[*][color=#000000][font=Palatino Linotype, serif][size=4]calcification foci with rounded contours, probably glossing over keratinous microcysts;[/size][/font][/color]
[*][color=#000000][font=Palatino Linotype, serif][size=4]a transversally cutted papillary mesenchymal body can be seen [size=4][color=#000000]on the upper right quadrant of the picture #6[/color][/size].[/size][/font][/color]
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DTE

If possible, I ask Dr. Mark Hurt to answer two questions, when closing the case: 1.Is there a mitotic figure in picture 7? 2. Is there a papillary mesenchymal body on the upper right quadrant of picture 6, as Robledo said?

I would like to ask you all if you would make this diagnosis straight on the H&E or would use a IHQ?
Thanks.

Thank you, Dr. Mark Hurt. I do not get good and clear results with CK20 too and I made only once the Androgen receptor that helped me in a superficial biopsy. I will read this article, I didn´t know about this fibroblast-activation protein.
Thank you again!

It is an H&E diagnosis (but Dr Akerman does state it can be one of the most difficult diagnoses in dermatopathology - I keep a spreadsheet wtih his 26 differentiating criteria!!). I find CK20 useful in small biopsies (almost always >5 MC in the basaloid cords, even in small biopsies), never seen any MC in an DTE-like infiltrative BCC. I have only collected about 20 or 30 DTE in my immuno database though (they are quite uncommon in my practice) but would be happy to collaborate on a bigger series. I have never seen prominent papillary mesenchymal bodies in DTE other than associated with trapped hair follicles (often numerous vellus follicles in cases of DTE that almost always occur on the central face).

Thanks Mark,
Here goes - you will tell something about my personality from this response!

Akerman uses the terms: Rims of compact collagen (encircling nests in DTE).
I like the curvilinear cords in DTE (but I have not recorded if that is distinguishing but looks very typical in your case).

Akerman's criteria are as follows (and I have been scoring cases prospectively):
1. Dell - not so useful in small biospies and not always present in DTE
2. Papillated epidermis (often in DTE, Flat in BCC) - not so useful
3. Symmetry (DTE yes; BCC no) - very useful in excision bx, obviously not helpful in small biopsies
4. Aggregations of larger size (DTE: No) - very useful
5. Variation in size and shapes (DTE: little variation) - very useful
6. Bizarre shapes (DTE: No) - very useful
7. Foci of typical (nodular) BCC (DTE: No) - very useful when present
8. Retraction artefact - not so helpful as absent usually in infiltrative BCC
9. Rims of compact collagen: DTE present around cords; not usually present in BCC - very useful
10. Squamous differentiation: DTE present in some aggregations (not in BCC) - not overly helpful
11. Follicular differentiation (hair bulbs, papillae, trichohyaline granules): (present in DTE) - not helpful
12. Aberrant follicles connected to epideris: (DTE may be present; absent in BCC) - not helpful
13. Aberrant hair shafts in nests: - not helpful
14. Epithelial keratin filled cysts: (numerous in DTE): very helpful
15. Shadow cells in cysts: not helpful
16. Granulomas around ruptured cysts: quite helpful
17. Calcification assoc. with keratin cysts: Very helpful
18. Sebaceous differnetiation: not helpful
19. Sebaceous cells around infundibular epithelium: not helpful
20. Mitotic figures (Rare in DTE): very helpul (Ki67 can be useful usually <5% in DTE often ~10% or greater in BCC)
21. Single cell necrosis / apoptosis: (absent in DTE): yes absent in DTE usually but can be quite low in infiltrative BCC
22. Melanocytic naevus (often present in DTE): only in one or two of our cases so not very helfpul!
23. Nerve and muscle (DTE not invaded): Bewared you can see perineural invasion within the confines of a DTE occasionally (I suspect this is under-recognised or has resulted in wrong classification as I did see previous Spot Diagnosis case).
24. Solar elastosis: Above stroma of DTE (admixed with tumour in BCC): My database indicates this criterion is useless!
25. Stromal fibroblasts (slight increase in DTE only, markedly increased in BCC): Quite useful
26. Lymphocytic infiltration (slight or absent in DTE): All DTE seem to lack inflammatory cell infiltrate in my database but I am not always sure inflammatory cells are prominent in BCC - could be useful if inflammation is prominent though.
Other comments: The DTE have not invaded subcutis but may be full thickness dermal (deepest in my series 2.5mm). Despite all these criteria a few cases in small biopsies I could not decide and in one or two of those sparse MC were noted. I usually advise complete excision with conservative margins (or margin control) for such (uncertain) cases. I also have two or three examples of collision tumours with DTE and infiltrative BCC - again MC with CK20 useful to illustrate in those cases. Hope this helps!

On the difference in the perception of the same object, here depicted by the presence or not of a papillary mesenchymal body on picture #6, please read this [url="https://dermpathpro.com/blog/3/entry-88-the-form-of-perception-and-the-object-of-perception/"]entry[/url] in Dr. Mark Hurt's Blog.