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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 754 - 8th May Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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76 years-old Hispanic female with right thigh 5.8 x 5.5 cm mass, present for 15 years.

Case posted by Dr. Hafeez Diwan.
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Go to records May 2013

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Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

I am thinking of pleomorphic hyalinizing angiectatic tumor of soft tissue.

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IgorSC

IgorSC 119

Posted

Great case! I also agree with Mona´s diagnosis, Pleomorphic hyalinizing angiectatic tumor with their viral-like cells similar to those seen in Myxoinflammatory fibroblastic sarcoma (some authors say there´s a relationship between them). I had 2 cases like this.

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Guest Romualdo C. L. Filho

Guest Romualdo C. L. Filho

Posted

PHAT.

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Robledo F. Rocha

Robledo F. Rocha 336

Posted

I encountered frequent neoplastic cells with too pronounced nuclear pleomorphism and I didn’t find any convincing intranuclear pseudoinclusion. Clear stromal areas may be reminiscent of myxoid matrix.
So, until immunohistochemical studies prove otherwise, I go with myxofibrosarcoma (or other related tumor) with PHAT-like vascular changes. Favor this hypothesis the history of a slowly growing tumor. Probably mitotic figures and thin-walled curvilinear vessels can be found elsewhere.

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Guest Bansal_

Guest Bansal_

Posted

Agree, pleomorphic hyalinising angiectatic tumour.

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Guest Rodrigo Restrepo

Guest Rodrigo Restrepo

Posted

Pleomorphic hyalinizing angiectatic tumor

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Guest Jim Davie MD

Guest Jim Davie MD

Posted

There are large floret-type vs. multinucleated atypical cells in the two center photos, and large telangiectatic vessels with a little hemosiderin. Fat necrosis with foamy histiocytes, fibrosis, and possibly dystrophic basophilic calcification (top left photo) seems to be a prevalent--if somewhat non-specific--finding.
Given the long-term 15 yr history, and low cellularity, I would favor trauma-related fat necrosis, or trauma-related hemosiderotic fibrohistiocytic lipomatous lesion (has floret cells, but usually distal extremity), in the differential diagnosis with PHAT. A stain for CD34 and CD68 may be of utility for differentiation.

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Guest BG
Ancient schwannoma.

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Dr. Hafeez Diwan

Dr. Hafeez Diwan 125

Posted

I called this pleomorphic hyalinizing angiectatic tumor.

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