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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 757 - 13th May Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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70 years-old male with a history of nodules and plaques on the abdomen.
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Guest Dr Engin Sezer

Guest Dr Engin Sezer

Posted

Epithelioid mailignant peripheral nerve sheath tumor (based on palisading pattern in Fig. 1 )

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Guest Dr Engin Sezer

Guest Dr Engin Sezer

Posted

History of NF??

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Guest
Merkel cell carcinoma vs lymphoma

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Sasi Attili

Sasi Attili 85

Posted

Would favour a high grade lymphoma, but need immunos to rule out poorly diff melanoma/ carcinoma's/ sarcoma

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Guest Zena Slim (SpR Wessex)

Guest Zena Slim (SpR Wessex)

Posted

A dense atypical lymphoid population with numerous blasts, apoptotic bodies and mitoses. I would favour tumour-stage Mycosis Fungoides. The possibilty of transformation to an anaplastic large cell lymphoma should also be considered.

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Guest Bansal_

Guest Bansal_

Posted

DD: high grade lymphoma (?DLBCL), melanoma, undiff carcinoma, sarcoma. On morphology, favour lymphoma.

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Eman El-Nabarawy

Eman El-Nabarawy 69

Posted

Favor B cell lymphoma.

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Guest Marcia

Guest Marcia

Posted

Favor lymphoma, diffuse large B cell lymphoma. Leg type?

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Guest Rodrigo Restrepo

Guest Rodrigo Restrepo

Posted

Large B cell lymphoma

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Robledo F. Rocha

Robledo F. Rocha 336

Posted

Sheets of cohesive large atypical cells extending into the subcutis comprising cells with irregularly indented nuclei, dispersed chromatin and prominent nucleoli. These microscopic findings and a case history of lesions confined to one anatomic region in an old man make me think of primary cutaneous anaplastic large cell lymphoma.
Immunophenotype study is vital to distinguish this hypothesis from other diffuse large cell lymphomas, like cutaneous follicle centre cell lymphoma with a diffuse growth pattern and tumor stage of mycosis fungoides with large cell transformation, and from diffuse large cell nonlymphoid neoplasms.

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Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

Thought of lymphoma: Anaplastic large TCL is my first impression. Considering the clincal localization to one region makes transformed tumor stage MF less likely. Definitely diffuse large BCL is a possibility. Immunophenotyping is mandatory.

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Guest Romualdo C. L. Filho

Guest Romualdo C. L. Filho

Posted

Large cell lymphoma. Diffuse large B cell lymphoma is my first possibility.

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Iskander H. Chaudhry

Iskander H. Chaudhry 49

Posted

Hello everyone! Thanks for your contributions today, the diagnosis is diffuse large B-cell lymphoma.

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Guest Hazem Hamed

Guest Hazem Hamed

Posted

Interesting case. Was EBER performed on this case? I would add EBER to the immuno panel to exclude DLBCL of the elderly.

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