Jump to content
In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 884 - 7th November Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)

60 year-old male with vulvar lesion.

Case posted by Dr. Hafeez Diwan.


  Report Record

User Feedback


Guest Maria George

Posted

Agree with Engin and with out history you may discuss chemotherapy effect.

Share this comment


Link to comment
share_externally

Guest Rodrigo Restrepo

Posted

Differentiated vulvar intraepithelial neoplasia

Share this comment


Link to comment
share_externally

Robledo F. Rocha

Posted

Is the patient a female one or a transsexual one with a neovulva?

Share this comment


Link to comment
share_externally

Guest Romualdo

Posted

In Picture # 4 there are some isolated large cells with large irregular nuclei and clear cytoplasm, in contrast to normal keratinocytes around them. I think this could be Paget's disease or, less probably, pagetoid VIN.

Share this comment


Link to comment
share_externally

Agree with VIN, but reluctant to make the diagnosis of differentiated VIN as it is rarely diagnosed in pure forms, usually adjacent to an invasive vulval SCC!!

Share this comment


Link to comment
share_externally

Robledo F. Rocha

Posted

Even though dysplastic keratinocytes can be found at all levels of the epidermis, the most atypical cells are confined to the lower one-third. So, I would call this VIN 1.

Share this comment


Link to comment
share_externally

Dr. Hafeez Diwan

Posted

The neoplastic cells are very hyperchromatic, instead of being the typical lighter pagetoid appearing ones. This is extramammary Paget's disease. CK7 and CEA were positive in the tumor cells. I have seen a few extramammary Paget's cases where the tumor cells were very hyperchromatic.

Share this comment


Link to comment
share_externally

Guest Maria George

Posted

Difficult case.Well done for [color=#1C2837][font=arial, verdana, tahoma, sans-serif][size=4][right]Romualdo who thought about the correct answer.[/right][/size][/font][/color]

Share this comment


Link to comment
share_externally



Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Add a comment...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...

×
×
  • Create New...