Case Number : Case 855 - 26th September Posted By: Guest

Mixed dermal lympho- mononuclear infiltrate. Some lymphoid cells are apparently sitting within larger elements. Wondering about cutaneous Rosai Dorfman disease, to start.

Agree: Rosai-Dorfman disease.

There certainly does appear to be emperipolesis supporting Rosai- Dorfman!
Would still do special stains to rule out an infective eitiology though.

Wow! This is the first time since I started answering the spot diagnosis, I thought about [font="arial, verdana, tahoma, sans-serif"][color="#1c2837"][size=4]Rosai-Dorfman disease as soon as I saw the slide and this does seem to be the consensus. Hope that is the answer![/size][/color][/font]

Agree

[size=4][color=#000000][font=Palatino Linotype, serif]Engulfment of leukocytes by histiocytes with abundant pale cytoplasm depicted in a beanbag pattern is characteristic for Rosai-Dorfman disease when accompanied by infiltrate of lymphocytes, plasma cells and neutrophils. Probably massive cervical lymphadenopathy, fever and polyclonal hypergammaglobulinemia are also present.[/font][/color]
[color=#000000][font=Palatino Linotype, serif]To be fair, [/font][/color][color=#000000][font=Palatino Linotype, serif]this disease was described first by the [/font][/color][color=#000000][font=Palatino Linotype, serif]French pathologist Pierre-Paul Louis Lucien D[/font][/color][color=#000000][font=Palatino Linotype, serif]é[/font][/color][color=#000000][font=Palatino Linotype, serif]stombes [/font][/color][color=#000000][font=Palatino Linotype, serif]in 1965, four years before than Juan Rosai and Ronald F. Dorfman[/font][/color][color=#000000][font=Palatino Linotype, serif] published their famous paper. What a pity [/font][/color][color=#000000][font=Palatino Linotype, serif]D[/font][/color][color=#000000][font=Palatino Linotype, serif]é[/font][/color][color=#000000][font=Palatino Linotype, serif]stombes [/font][/color][color=#000000][font=Palatino Linotype, serif]wrote his article in French, [/font][/color][color=#000000][font=Palatino Linotype, serif]not in English like Rosai and Dorfman[/font][/color][color=#000000][font=Palatino Linotype, serif]![/font][/color][/size]

Rosai Dorfman Disease

Agree with DRD / RD. Alternatively known as "sinus histiocytosis with massive lymphadenopathy" although this is a poor synonym, given its potential for exclusively extra-nodal distribution. The clinical is non-classic for DRD ....which is most often a disease of young adults.

It would be interesting to see the immunostains and/or clinical workup, if confirmation was sought.

Rosai-Dorfman disease. The histiocytic cells were S-100 positive.