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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1079 - 12th August Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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24 year old male newly diagnosed with HIV. Biopsy of left thigh.

Case posted by Dr.Uma Sundram.


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Uma Sundram

Posted

[img]https://dermpathpro.com/uploads/spot_diagnosis_comment_img/CASE1079_SD-US-007-F5.jpg[/img]
Can you all guess the immunohistochemical study and the diagnosis?

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Uma Sundram

Posted

By the way...the brown wiggles are not melanin.

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Uma Sundram

Posted

Yes, I called this secondary syphilis. The immunohistochemical stain is a spirochete stain. I hought this was a good example of needing to have a broad differential on light microscopy in newly diagnosed HIV patients since syphilis can mimic a lot of other entities, and can have more interface than granulomatous features.

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