Jump to content
In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 944 - 4th February Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)
The patient is a 76 year old woman with a shave biopsy taken from the left temple.

Case posted by Dr. Mark Hurt
picture-1
picture-2
picture-3
picture-4
picture-5
picture-6
picture_7
picture_8
  Report Record
Go to records February 2014

User Feedback


Eman El-Nabarawy

Eman El-Nabarawy 69

Posted

Melanoma with balloon or clear cell changes.

Share this comment

Link to comment
share_externally
Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

Melanoma with focal clear cell change...

Share this comment

Link to comment
share_externally
Guest havva gökçe

Guest havva gökçe

Posted

favour baloon cell melanoma, ihc needed.

Share this comment

Link to comment
share_externally
IgorSC
Baloon cell melanoma. I think the lentiginous proliferation and the focal cellular nests speaks against Sebaceous carcinoma, but this is a good differential diagnosis. I would perform IHQ. Probably amelanotic (no pigments and the shave procedure).

Share this comment

Link to comment
share_externally
Robledo F. Rocha

Robledo F. Rocha 336

Posted

Both sebaceous carcinoma and clear cell melanoma may show pagetoid spread and bubbly cytoplasm, but I favor the latter because the lentiginous pattern of growth along the dermoepidermal junction.

Share this comment

Link to comment
share_externally
Guest Maria George

Guest Maria George

Posted

Similar to yesterday game.SCC vs AX vs melanoma. In this case you may add Seb. ca for IHC.

Share this comment

Link to comment
share_externally
Guest Jim Davie MD

Guest Jim Davie MD

Posted

I favor invasive clear cell SCC.

The left images on the 2nd, 3rd, and 4th rows show clear intraepidermal cells with linear vs. elongated nested distribution along the junction, but to my eye, they seem placed suspiciously above (rather than below) the epidermal basement membrane. Some cells in my opinion show subtle features of keratinocytes.

I agree with the differential of clear cell melanoma, vs. Seb Ca. Immunostains will differentiate; PAS +/- diastase for assessment of glycogen content may be of additional utility.

Share this comment

Link to comment
share_externally
Guest Engin Sezer

Guest Engin Sezer

Posted

S100, adidophilin and MNF-116 for Dx. Probably balloon cell melanoma

Share this comment

Link to comment
share_externally


Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Add a comment...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...
×

×
×
  • Create New...