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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1050 - 2nd July Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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59 year-old female with renal disease. This biopsy is from the left leg.

Case posted by Dr. Hafeez Diwan.


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Dr. Mona Abdel-Halim

Posted

Yes, calciphylaxis

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Robledo F. Rocha

Posted

Agree with calciphylaxis, a variant of metastatic calcification mostly associated to end-stage renal failure. But what about the non-inflammatory subepidermal blister with dermal papillae festooning and the hyalin thickening of vascular walls with dermal hemorrhage? Could these findings mean pseudoporphyria, a bullous condition which may occur in patients with chronic renal failure undergoing hemodialysis? Or systemic amyloidosis, a possible cause of the renal disease in our patient? Or are they just secondary ischemic alterations due to calciphylaxis?

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Dr. Hafeez Diwan

Posted

Calciphylaxis. I think the findings seen in the dermis are secondary to calciphylaxis.

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