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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1028 - 2nd June Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)
The patient is a 74 year old man with a shave biopsy of a lesion on the right side of the scrotum.

Case posted by Dr. Mark Hurt.
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Go to records June 2014

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nick turnbull

nick turnbull 7

Posted

Hmm..Heavily inflamed and spongiotic fbroepithelial polyp, with markerd parakeratosis with numerous neutrophils, reactive pagetoid dyskeratosis and verrucous xanthoma. I would wonder about trauma, infection (didn't see any fungi or bacteria), infestation (scabies), and contact/irritant dermatitis. Way off?

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Eman El-Nabarawy

Eman El-Nabarawy 69

Posted

Verruciform xanthoma.

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Arti Bakshi

Arti Bakshi 286

Posted

Agree with Verruciform xanthoma.
There is evidence of keratinocyte necrosis in image 2 and 3, which is thought to be pathogenic in causing macrophage influx and xanthomatisation.

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Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

Verruciform xanthoma

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Robledo F. Rocha

Robledo F. Rocha 336

Posted

Verruciform xanthoma.

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Guest Tiberiu Tebeica

Guest Tiberiu Tebeica

Posted

Verruciform xanthoma, which is fairly common on the scrotum.

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Guest Omobolade Obadofin

Guest Omobolade Obadofin

Posted

Classical Veruciform xanthoma. Nice case.

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Robledo F. Rocha

Robledo F. Rocha 336

Posted

[quote name='arti bakshi' timestamp='1401709557']
Agree with Verruciform xanthoma.
There is evidence of keratinocyte necrosis in image 2 and 3, which is thought to be pathogenic in causing macrophage influx and xanthomatisation.
[/quote]
Very interesting this pathogenic hypothesis, Dr. Bakshi. I remember an ultrastructural study performed by [url="http://www.jaad.org/article/0190-9622(91)70117-K/abstract"]Balus et cols.[/url] which have suggested a transferation of lipid droplets from the cytoplasm of the melanocytes in the basal layer of the epidermis to the unknown-lineage foam cells that house in the in the dermis between rete pegs.

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