Jump to content
In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1007 - 2nd May Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)

M75.?BCC on scalp.

Case posted by Dr. Richard Carr.


  Report Record

User Feedback


Dr. Mona Abdel-Halim

Posted

Well differentiated seb carcinoma

Share this comment


Link to comment
share_externally

Guest Romualdo

Posted

Agree, sebaceous carcinoma with squamous differentiation (squamoid variant).

Share this comment


Link to comment
share_externally

Dr. Richard Carr

Posted

You will need to re-think. Immunos to be posted at 4pm British Summer Time!

Share this comment


Link to comment
share_externally

Dr. Mona Abdel-Halim

Posted

If not sebaceous, then Clear Cell SCC which is more favored over Clear cell hidradenocarcinoma.. Immunos will solve...

Share this comment


Link to comment
share_externally

Dr. Richard Carr

Posted

Okay Iskander's team must be busy as I have had not acknowledegment so I will have to describe the IHC. The epithelial component (about 30% of the combined tumour) is diffusely p63 and pan-keratin positive and also is widely strongly BerEP4 positive but EMA negative. The foamy cells are negative for all epithelial markers and weakly express CD68 only. I did not do vimentin!

Share this comment


Link to comment
share_externally

Dr. Mona Abdel-Halim

Posted

Epithelial component: BCC ( BerEP4 positive, EMA negative)
The foamy cell component: not epithelial, CD68 positive
This is a collision tumor of a BCC and AFX (clear cell variant).

Share this comment


Link to comment
share_externally

Dr. Richard Carr

Posted

Well done Mona - I reported it as a partly basosquamous BCC with sarcomatoid component (clear cell AFX-type). Obviously we only have the top of the specimen and would have to re-assess on a complete excision to see if the sarcomatoid component was more deeply invasive etc. This was a very difficult case and illustrates that sebocyte-like differentiation is not necessarily true sebaceous differentiation.

Share this comment


Link to comment
share_externally

Guest Jim Davie MD

Posted

Very nice case. For sake of the differential, clear cell melanoma may also be a consideration ... can be CD68 positive and CK negative. Any melanocytic markers performed?

Share this comment


Link to comment
share_externally



Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Add a comment...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...

×
×
  • Create New...