Case Number : Case 1129 - 21st October Posted By: Guest

Beautiful!

Non-inflammatory decrease in the epidermal pigment intensity and normal number of melanocytes, suggestive of progressive macular hypomelanosis. Ash leaf spots of tuberous sclerosis must be considered, too.

Yes, very beautiful, very typical clear cell papulosis.. Typical site

Clear cells among basal cells and supra basal consistent with clear cell papulosis. Very nice

Agree with Mona and Sadat: clear cell papulosis.

What about nevus depigmentosus? Clear cell papulosis is a nice possibility but it presents with papules not macules as in our case!!

[img]https://dermpathpro.com/uploads/spot_diagnosis_comment_img/CASE1129_SD_US_017_F4.jpeg[/img]

[img]https://dermpathpro.com/uploads/spot_diagnosis_comment_img/CASE1129_SD_US_017_F5.jpeg[/img]

We thought this was a great case of clear cell papulosis. The first immunohistochemical image is that of CK7 and the second of BRST-2. Increase in the presence of these types of clear cells, together with the clinical setting, led us to make the diagnosis of clear cell papulosis. We published this case report in Pediatric Dermatology and the reference has great clinical photos: here's the reference-
[url="http://www.ncbi.nlm.nih.gov/pubmed/22142549"]Clear-cell papulosis: a rare entity that may be misconstrued pathologically as normal skin.[/url]
Wysong A, [b]Sundram U[/b], [b]Benjamin L[/b].
Pediatr Dermatol. 2012 Mar-Apr;29(2):195-8.