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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1112 - 26th September Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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M80 Back. 10 x 9mm lesion ?Cystic BCC

Case Posted by Dr Richard Carr


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Dr. Mona Abdel-Halim

Posted

Clear cell SCC more than trichilemmal carcinoma

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Guest Romualdo

Posted

Nodular hidradenoma. If there are moderate numbers of mitotic figures, then atypical nodular hidradenoma.

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Robledo F. Rocha

Posted

[left]Neoplastic cells seem to bail out from epidermis and, in the two bottom images, some neoplastic cells give evidence of squamous differentiation. So, my first impression is squamous cell carcinoma.[/left]

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Guest Giovanni Falconieri

Posted

I think it is malignant. Metastatic carcinoma might be also added to the differential

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Mark A. Hurt MD

Posted

I favor BCC with clear-cell changes. I considered sebaceous carcinoma, but it lacks the “bubbliness” in the clear cells.

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Dr. Richard Carr

Posted

The was a case that has a differential diagnosis of tricholemmal carcinoma v's basal cell carcinoma with tricholemmal differentiation v's tricholemmoma. The immunostains helped a bit weak focal peripheral BerEP4 only (against BCC) and negative CD34 (against tricholemmoma) therefore favoured a tricholemmal carcinoma (variant of follicular SCC). No ducts or lumina to suggest hidradenoma. The lesion was relatively circumscribed and completely excised so only of academic interest. In our view circumscript tciholemmoal carcinoma (a variant of follicular infundibular-tricholemmal SCC) has no potential for metastasis - still unpublished observations but hopefully to submit this winter).

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