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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
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Case Number : Case 1341 - 13 August Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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53 year-old female with metastatic breast carcinoma who presented with a maculopapular rash. This biopsy is from the abdomen.

Case posted by Dr Hafeez Diwan
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Go to records August 2015

User Feedback


Arti Bakshi

Arti Bakshi 286

Posted

?epidermotropic metastatic carcinoma. (will need immunos to confirm and exclude pagetoid Bowens). Very unusual presentation!

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Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

Yes, agree with Arti. Epidermotropic metastatic carcinoma. The clinical description of maculopapular eruption speaks against Bowen's.

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Guest Romualdo

Guest Romualdo

Posted

I think these atypical cells are keratinocytes. In my oppinion this is a toxic effect of a chemotherapeutic drug.

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Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

Good suggestion Romualdo, but with the cell with signet ring appearance in the third image I think metastasis is favored. Besides, as much as I remember, the keratinocyte toxic reactions to chemotherapeutics does not produce specific clinical reactions, they r found as incidental changes in skin biopsies of other lesions as much as I remember. Anyways, immunos r needed..

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IgorSC
Really nice case!
I agree with epidermotropic metastasis. IHQ needed.

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Dr. Hafeez Diwan

Dr. Hafeez Diwan 125

Posted

I called this chemotherapy effect.

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