Case Number : Case 1430- 16 December Posted By: Guest

I propose an adnexal neoplasm arising on a contex of balanitis xerotica obliterans. It looks like a papillary eccrine neoplasm with intracelular pigmentation (hemosiderin?). I have read that complex adnexal neoplasms arise on penis but I find hard to perform an specific diagnosis  based only on these images. Makes me think a bit of syringocistadenoma papilliferum

Difficult case. Lichen sclerosus associated with cystic ectopic prostatic tissue? Lipofuscin pigment granules are present in apical cytoplasm of secretory cells.

I see two unrelated lesions. There´s a Lichen sclerosus and a lesion that is compoed of a columnar epithelium with some pigments, like Raul said. I believe this is a median raphe cyst. In some of these cysts there´s pigmentation due to the presence of melanocytes proliferating within the cyst.

another differential a papillary hidrocystoma

Agree with Igor on the differential of median raphe cyst

Urethral caruncle on a context of penile amyloidosis and...what are that round bodies? amoebas? penile amoebiasis?

I agree with Sasi!

I have never seen a urethral caruncle in a male, but i'm observing something so resembling!

Lichen sclerosus+ median raphe cyst. The latter can rarely have melanin. Looks more like lipofuschin here. Some resemblance to hidrocystoma also seen.

Lichen sclerosus clearly explains the phimotic foreskin.

Interesting cyst…agree with Sasi that difficult to reconcile with the fact that this wasn't noted clinically!

There are papillary infolding, intraluminal secretions, pseudo stratified epithelium with snouting  and pigment. The pigment looks more lipofuscin to me than melanin. So, like Romualdo's suggestion of ectopic prostatic tissue …or even ectopic seminal vesicle!!

Always consider the possibility of an error.  The cyst is not in the low powers after all.  Also like Romualdo's suggestion although I was thinking of a apocrine cystadenoma (can have lipofuscin++).

Aside: I once saw a case of lentigo maligna in one whole cross-section of a case of a lesion removed from the leg of a relatively young person and the pathologist reported it as melanoma in situ despite there being lot's of solar elastosis and sebaceous units confined the the "floating" section.  I also remember the same happening in a referral case on a foot lesion one piece with a carcinoma clearly did not look like foot skin.

I agree with Dr Carr.  We need a low power view to see if and how the two pathologies are related. 

I should have included a low power shot.  The cyst was in the same piece of tissue as the rest.  It is lined by pseudostratified epithelium, and so I called this lichen sclerosus with an associated median raphe cyst.

Dr. Hafeez Diwan, what is the nature of the pigment, melanin or lipofuscin?