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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1196 - 22nd January Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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Biopsy from a vaccination site.

Case posted by Dr Hafeez Diwan


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Dr. Mona Abdel-Halim

Posted

Aluminium (adjuvant in vaccines) induced granuloma...

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Guest Jim Davie MD

Posted

There appears to be a leukocytoclastic vasculitis component with focal necrosis; would add local hypersensitivity Type III reaction (Arthus reaction) to the differential, depending on the clinical context. Arthus reactions have been infrequently reported after vaccinations containing diphtheria and tetanus toxoid.

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Robledo F. Rocha

Posted

Epidermis is necrotic and keratinocytes show intracytoplasmatic eosinophilic inclusions suggestive of Guarnieri’s bodies. Local vaccinia vaccination site reaction is my choice.

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Dr. Mona Abdel-Halim

Posted

Nice idea Robledo :-))
I think I interpreted image 3 wrong...
I re-examined the photos again
Would like to suggest now: chicken pox like rash at site of varicella vaccine...

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Dr. Hafeez Diwan

Posted

This is an ancient case from our files, and it a biopsy of a smallpox vaccination site.

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The idea of cowpox did cross my mind, but I confess I didn't think this would be the answer.

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Dr. Richard Carr

Posted

How annoying as I thought these were Guarneri bodies and even tried to look up [u][b]live[/b][/u]pox virus vaccines and could not find any in current usage. I did not think to go back in history!!!!

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