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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1324 - 21 July Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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35 year old male with numerous papules forming a lacy annular pattern on the glans penis. A p16 was performed.

Case posted by Dr Uma Sundram


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Dr. Mona Abdel-Halim

Posted

The histopathology and the clinical are typical of LP (genital LP). The strong P16 positivity is also found in LP. Nice :-)

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Eman El-Nabarawy

Posted

I agree that both clinical picture and histopathological findings are classic of LP. however, I am still worried about the band-like staining of P16 (seen in cases of Intraepithelial neoplasia) so I'd like to do Ki67.

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Arti Bakshi

Posted

Histology typical of lichen planus. Not sure why the p16 was done, as no obvious cytological atypical. Does the diffuse positivity indicate greater risk of malignant transformation??

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Uma Sundram

Posted

Lichen planus. This case belonged to a colleague of mine and I wanted to include p16 to show the level of positivity that can be seen in LP. Important to correlate with cytology as pointed out by arti. Ki67 very low and this level of p16 positivity is not significant in this context.

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