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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1302 - 19 June Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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F68. Lump in 4th webspace of right hand

Case posted by Dr Richard Carr


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Dr. Mona Abdel-Halim

Posted

Adult myofibroma

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Guest Romualdo

Posted

Although these are related tumors the absence of a biphasic pattern and the distinctly perivascular arrangement of myoid cells are typical of myopericytomas, in this case an intravascular one.

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Eman El-Nabarawy

Posted

Based on: the age, the onion-ring appearance, myopericytoma Is my diagnosis.Some reports regard myopericytoma as a part of the spectrum of angioleiomyoma.

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Dr. Mona Abdel-Halim

Posted

According to McKee's pathology of skin: solitary myofibromas may show minimal to absent primitive component. In addition according to McKee's pathology of skin, in recent years the term myopericytoma represent a spectrum that includes tumors classified in the past as glomangiopericytoma, myopericytoma, adult myofibroma and myofibromatosis in adults. So according to recent terminologies, may be it is better to call this lesion myopericytoma as Hazem and Romualdo said.

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Dr. Richard Carr

Posted

[img]https://dermpathpro.com/uploads/spot_diagnosis_comment_img/Case%201302_RAC7153x10_SMA_4pm.jpg[/img]

[img]https://dermpathpro.com/uploads/spot_diagnosis_comment_img/Case%201302_RAC7153x10b_CD34_4pm.jpg[/img]

[img]https://dermpathpro.com/uploads/spot_diagnosis_comment_img/Case%201302_RAC7153x10b_Desmin_4pm.jpg[/img]

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Guest Hazem Hamed

Posted

I think this immunoprofile together with the morphology support the diagnosis of myopericytoma

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Myopericytoma.

Angioleiomyomas are subcutaneous and contain thick-walled muscular vessels interspersed in what would otherwise be a leiomyoma. I don't think that's the case here.

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Dr. Richard Carr

Posted

I thought this was an angioleiomyoma / myopericytoma overlap. I asked Thomas Mentzel to comment as I have only seen one or two of these rare tumours. He commented as follows:
Dear Richard,
thanks and I think that myopericytoma is a good differential diagnosis, however, usually these lesions are desmin negative! So probably, it represents rather an angioleiomyoma with some similarities to myopericytoma and we know that there are overlaping features emphasizing the hypothesis of a spectrum of perivascular myoid neoplasms including glomus tumour, myopericytoma, angioleiomyoma and myofibroma.
Best wishes
Thomas

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