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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1268 - 04 May Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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The patient is a 53 year old woman with a punch biopsy of a 13 mm psoriasiform patch taken from the right nipple. Clinical Diagnosis: Basal cell carcinoma vs squamous cell carcinoma vs Paget's.

Case posted by Dr Mark Hurt
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Go to records May 2015

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Dr. Mona Abdel-Halim

Dr. Mona Abdel-Halim 508

Posted

Paget's. CAM5.2 positivity is against pagetoid Bowen's.

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IgorSC

IgorSC 119

Posted

I agree with Paget´s disease diagnosis.

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Guest Romualdo

Guest Romualdo

Posted

Agree, Paget's disease.

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Dr. Richard Carr

Dr. Richard Carr 622

Posted

Mark,
Did you consider these papillary dermal cells may be necrotic neoplastic cells that have dropped out akin to colloid bodies or was there visibile invasion on H&E
Regards
Richard

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Dr. Richard Carr

Dr. Richard Carr 622

Posted

No I have not but looking at the images my impression was they were limited to the papillary dermis and smaller than the cells in the epidermis - perhaps shrunken - you would be better to judge of course. Dual IHC might be of interest e.g. Ki67/Cam5.2 to see if they are still in cell cycle?
Regards
Richard

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