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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1514 - 13 April Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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36 year old male with skin disorder from birth. This is a random biopsy from the back. (Courtesy of Dr. Sarah Galfione.)

Dr Hafeez Diwan.


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vincenzo polizzi

Posted

I thought Ichthyosis vulgaris...but from birth?

on the other hand i don't see any granular layer

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Raul Perret

Posted

Agree with Ichthyosis, not vulgaris but probably X linked due to the basal vacuolar degeneration and hyperkeratosis of folicular and sweat duct orifices. Fits better with the clinical (male patient lesions present since birth)

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Agree with ichthyosis.  I cannot differentiate, on microscopy, between ichthyosis vulgaris, lamellar ichthyosis and X-linked ichthyosis. 

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The hyperkeratosis along with the hypogranulosis makes me think in Ichthyosis vulgaris too.

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Guest Arash Daryakarr

Posted

I Agree with colleagues,too

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Dr. Mona Abdel-Halim

Posted

The absent stratum granulosum is striking, fits with ichthyosis vulgaris

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Dr. Hafeez Diwan

Posted

The pictures I took don't show the granular layer, but it is present.  So sorry about that!  This was reportedly a case of lamellar ichthyosis.

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