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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1457- 25 January Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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Case History: The patient is a 53-year-old man with a biopsy of a lesion on the left anterior thigh.

Case posted by Dr Mark Hurt


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Raul Perret

Posted

Ossifying dermatofibroma with osteoclast-like giant cells

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Raul Perret

Posted

Am j Dermatopathol. 2009 Jun;31 (4) :379-83

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vincenzo polizzi

Posted

What about a Extrasrticular Ossifying Pigmented villonodular synovitis?

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Nitin Khirwadkar

Posted

Agree. Did think about a soft tissue giant cell tumour as a differential. However, this case lacks the peripheral ossification usually seen with giant cell tumours. Not sure if cases of ossifying DFs have this uniform distribution of osteoclastic giant cells. The central bone formation and osteoblastic rimming, along with other features is more in favour of ossifying dermatofibroma.

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Dr. Mona Abdel-Halim

Posted

Yes agree with Raul, very nice :-)

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Dr. Mona Abdel-Halim

Posted

I thought of giant cell tumor of soft tissue first but after reading Raul's suggestion, I read the article he mentioned and found that it fits very much with the reported ossified DF with osteoclast like giant cells. I have not find ossification in giant cell tumor of soft tissue... Interesting case..

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Nitin Khirwadkar

Posted

Read this from the chapter of 'tumours of osteoarticular origin' in Diagnostic Histopathology of tumours 3rd edition. Not sure how this translates to cutaneous lesions.

'a rare giant cell tumour shows new bone formation within the substance of the tumour'.

There is another comment regarding 'fibrous histiocytoma like areas within GCT'.

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