Case Number : Case 1891 - 28 Aug - Dr Limin Yu Posted By: Guest

Trichoblastoma, large nodular and pigmented, HMB45?

Pigmented Trichoblastoma

Agree, Trichoblastoma. Listen, SOMEBODY COULD HELP ME? SPOT DIAGNOSTIC IS FREE, BUT I PAID A FULL MEMBERSHIP SUBSCRIPTION TO STUDY AND THE ONLINE COURSES, SPECIAL MODULES AND SOME VIDEOS AREN´T WORKING. I wrote to the website administrator a couple of times but don´t have answers yet.

My impression is there are many dendritic melanocytes (pic3/4), so I would like to name this Melanotrichoblastoma...what do you guys think about?

Agree with Vincenzo

39 minutes ago, vincenzo polizzi said:

My impression is there are many dendritic melanocytes (pic3/4), so I would like to name this Melanotrichoblastoma...what do you guys think about?

I think that if HMB45 shows hyperplasia of melanocytes I would agree with you and propose to publish it my friend (if the case was ours of course)

Agree with the diagnosis of pigmented trichoblastoma associated with hyperplasia of melanocytes. 

9 hours ago, Victor Delgado said:

Agree, Trichoblastoma. Listen, SOMEBODY COULD HELP ME? SPOT DIAGNOSTIC IS FREE, BUT I PAID A FULL MEMBERSHIP SUBSCRIPTION TO STUDY AND THE ONLINE COURSES, SPECIAL MODULES AND SOME VIDEOS AREN´T WORKING. I wrote to the website administrator a couple of times but don´t have answers yet.

Jen our admin office will be responding to your email today. 

Thank everyone for the insightful discussion. I agree with everyone that this is a  benign neoplasm with follicular differentiation.  I am mostly impressed by the recapitulation of the follicle matrix -- so I made the diagnosis of melanocytic matricoma. I'm not aware of a set of criteria that can reliably distinguish it from trichoblastoma. In my opinion they are in the same spectrum. I'm open to any advice. Thanks!

On ‎31‎/‎08‎/‎2017 at 07:48, Limin Yu said:

Thank everyone for the insightful discussion. I agree with everyone that this is a  benign neoplasm with follicular differentiation.  I am mostly impressed by the recapitulation of the follicle matrix -- so I made the diagnosis of melanocytic matricoma. I'm not aware of a set of criteria that can reliably distinguish it from trichoblastoma. In my opinion they are in the same spectrum. I'm open to any advice. Thanks!

Dear Limin,

I have a collection of melanocytic matricomas and they don't have papillary mesenchymal cells and do have matrical keratin and usually are diffusely Beta-catenin positive. Your case looks like a typical example of a pigmented trichoblastoma to me.

Regards

Richard