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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1891 - 28 Aug - Dr Limin Yu Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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23 yo male scalp bx

Edited by Admin_Dermpath


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Raul Perret

Posted

Trichoblastoma, large nodular and pigmented, HMB45?

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Victor Delgado

Posted

Agree, Trichoblastoma. Listen, SOMEBODY COULD HELP ME? SPOT DIAGNOSTIC IS FREE, BUT I PAID A FULL MEMBERSHIP SUBSCRIPTION TO STUDY AND THE ONLINE COURSES, SPECIAL MODULES AND SOME VIDEOS AREN´T WORKING. I wrote to the website administrator a couple of times but don´t have answers yet.

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vincenzo polizzi

Posted

My impression is there are many dendritic melanocytes (pic3/4), so I would like to name this Melanotrichoblastoma...what do you guys think about?

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Raul Perret

Posted (edited)

39 minutes ago, vincenzo polizzi said:

My impression is there are many dendritic melanocytes (pic3/4), so I would like to name this Melanotrichoblastoma...what do you guys think about?

I think that if HMB45 shows hyperplasia of melanocytes I would agree with you and propose to publish it my friend (if the case was ours of course)

Edited by Raul Perret

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Cem Leblebici

Posted

Agree with the diagnosis of pigmented trichoblastoma associated with hyperplasia of melanocytes. 

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Admin_Dermpath

Posted

9 hours ago, Victor Delgado said:

Agree, Trichoblastoma. Listen, SOMEBODY COULD HELP ME? SPOT DIAGNOSTIC IS FREE, BUT I PAID A FULL MEMBERSHIP SUBSCRIPTION TO STUDY AND THE ONLINE COURSES, SPECIAL MODULES AND SOME VIDEOS AREN´T WORKING. I wrote to the website administrator a couple of times but don´t have answers yet.

Jen our admin office will be responding to your email today. 

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Thank everyone for the insightful discussion. I agree with everyone that this is a  benign neoplasm with follicular differentiation.  I am mostly impressed by the recapitulation of the follicle matrix -- so I made the diagnosis of melanocytic matricoma. I'm not aware of a set of criteria that can reliably distinguish it from trichoblastoma. In my opinion they are in the same spectrum. I'm open to any advice. Thanks!

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Dr. Richard Carr

Posted

On ‎31‎/‎08‎/‎2017 at 07:48, Limin Yu said:

Thank everyone for the insightful discussion. I agree with everyone that this is a  benign neoplasm with follicular differentiation.  I am mostly impressed by the recapitulation of the follicle matrix -- so I made the diagnosis of melanocytic matricoma. I'm not aware of a set of criteria that can reliably distinguish it from trichoblastoma. In my opinion they are in the same spectrum. I'm open to any advice. Thanks!

Dear Limin,

I have a collection of melanocytic matricomas and they don't have papillary mesenchymal cells and do have matrical keratin and usually are diffusely Beta-catenin positive. Your case looks like a typical example of a pigmented trichoblastoma to me.

Regards

Richard

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