Case Number : Case 1866 - 24 July - Dr Limin Yu Posted By: Guest

amyloid

Agree, amyloidosis.

Amyloidosis of the ear, lovely case :-)

Agree with Colleagues. Nice case. 

Agree, amyloid.

Hi All 

Image 5 is Congo Red and Image 6 Crystal violet stain. Provided by Dr Limin Yu. 

DermpathPRO Admin 

?colloid milium

2 hours ago, urmilapandey said:

?colloid milium

type IV collagen, laminin or electron microscopy would help for this differential, but do we really need to do it? I would just mention it in the report.

1 hour ago, Raul Perret said:

type IV collagen, laminin or electron microscopy would help for this differential, but do we really need to do it? I would just mention it in the report.

me too

Thank everyone for the profound discussion. Actually this patient has a history of smoldering multiple myeloma. The case was signed-out as amyloidosis. 

Colloid milium is a great differential diagnosis. Sometimes, it's indistinguishable from amyloidosis histologically. In this clinical setting (patient's history and lesion location), amyloidosis is more appropriate. 

I thought about using the term "auricular amyloidosis" to be more specific in terms of the biopsy location. But I didn't use it due to the potential confusion to my clinician colleagues.