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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1866 - 24 July - Dr Limin Yu Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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78F, Biopsy of left ear external canal.

Edited by Admin_Dermpath


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Dr. Mona Abdel-Halim

Posted

Amyloidosis of the ear, lovely case :-)

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vincenzo polizzi

Posted

Agree with Colleagues. Nice case. 

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Admin_Dermpath

Posted

Hi All 

Image 5 is Congo Red and Image 6 Crystal violet stain. Provided by Dr Limin Yu. 

DermpathPRO Admin 

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urmilapandey

Posted (edited)

?colloid milium

Edited by urmilapandey

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Raul Perret

Posted

2 hours ago, urmilapandey said:

?colloid milium

type IV collagen, laminin or electron microscopy would help for this differential, but do we really need to do it? I would just mention it in the report.

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urmilapandey

Posted

1 hour ago, Raul Perret said:

type IV collagen, laminin or electron microscopy would help for this differential, but do we really need to do it? I would just mention it in the report.

me too

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Limin Yu

Posted

Thank everyone for the profound discussion. Actually this patient has a history of smoldering multiple myeloma. The case was signed-out as amyloidosis. 

 

Colloid milium is a great differential diagnosis. Sometimes, it's indistinguishable from amyloidosis histologically. In this clinical setting (patient's history and lesion location), amyloidosis is more appropriate. 

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Limin Yu

Posted

I thought about using the term "auricular amyloidosis" to be more specific in terms of the biopsy location. But I didn't use it due to the potential confusion to my clinician colleagues. 

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