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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1846 - 26 June - Dr Limin Yu Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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Clinical History: 57 F nose, clinical suspicion: BCC.

Case Posted by Dr Limin Yu


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Admin_Dermpath

Posted

Dr Limin Yu has a great case for you in his last posting of this month.

Geoff Cross - DermpathPRO Projects

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dermpath1

Posted

Giant cell collagenoma (GCC) .The differentials include multinucleate cell angiohistiocytoma , circumscribed storiform collagenoma, pleomorphic fibroma, regressive forms of dermatofibroma, and solitary myofibroma .

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dermpath1

Posted

If we agree that the giant cells seen are of the floret-type, then we may say that these cells can be seen in skin pathology in some conditions such as  pleomorphic lipoma,  giant cell fibroblastoma , neurofibroma, giant cell angiofibroma and giant cell collagenoma.

The last 3 conditions might be pertinent to this particular case.

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Robledo F. Rocha

Posted

Pleomorphic fibroma of the skin. A spindle cell tumor showing multinucleated giant cells that have large pleomorphic and hyperchromatic nuclei, within a dense collagenous background.

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Dr. Mona Abdel-Halim

Posted

Giant cell collagenoma

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vincenzo polizzi

Posted

I think this could be an example of fibrous papule of the nose, pleomorphic/giant cell variant.

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Dr. Mona Abdel-Halim

Posted

28 minutes ago, vincenzo polizzi said:

I think this could be an example of fibrous papule of the nose, pleomorphic/giant cell variant.

Good suggestion :-)

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Raul Perret

Posted

For me this is more consistent with pleomorphic fibroma but I would not mind if someone called this pleomorphic variant of fibrous papule of the nose

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Limin Yu

Posted

Thank everyone for your profound insights!

 

This is a FP to me. It's more sclerotic than what's typically seen. That's why I thought it would be a good case to share. 

 

Pleomorphic fibroma is a ddx to consider.  The reason I did not go this route is because the atypical cells in this case are not too atypical. I understand this is subtle and the difference is only in the eyes of beholders. 

 

Thank everyone for your time and discussion. 

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