Jump to content
In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1931 - 24 Oct - Dr Arti Bakshi Posted By: Guest

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)

6 week history of 4cm cutaneous swelling on chest wall. Punch bx.


  • Like 1
  Report Record

User Feedback


vincenzo polizzi

Posted

Looks like a myeloid sarcoma/AML...( high magnification shows some eosinophilic precursor cell )

Share this comment


Link to comment
share_externally

Agree, sheets of dyshesive atypical cells sparing the epidermis, most likely leukemia cutis. Unless clinically known and characterized, a broad IHC panel is indicated to pin down the phenotype and rule out other hematologic malignancies. I would do CD45, CD43, CD34, CD117, lysozyme, CD4, CD20, CD30, CD56 depending upon overall consideration.

Share this comment


Link to comment
share_externally

Dr. Mona Abdel-Halim

Posted

Yes, my first though was myeloid sarcoma/AML for IHC

Share this comment


Link to comment
share_externally

Arti Bakshi

Posted

The initial immunoprofile was as following:

LCA positive

CD3, CD20, TdT, MPO, CD117, CD34, CD5, CD30, EBER all negative.

Any suggestions for further immunos/ diagnoses??

 

Share this comment


Link to comment
share_externally

vincenzo polizzi

Posted (edited)

CD56? CD123?

Edited by vincenzo polizzi

Share this comment


Link to comment
share_externally

CD43 is most sensitive for Leukemia cutis, so I would definitely do that, and also throw in lysozyme.

CD4, CD123, CD56 and TCL1 for BPDCN. 

Share this comment


Link to comment
share_externally

Arti Bakshi

Posted

Yes, this is Blastic Plasmacytoid Dendritic Cell neoplasm.

The tumour cells were diffusely positive for CD4, CD56 and CD123.

Well done to Vincenzo and VParekh!

Share this comment


Link to comment
share_externally



Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Add a comment...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...

×
×
  • Create New...