Case Number : Case Number : Case 1910- 22 Sept - Dr Iskander Chaudhry Posted By: Guest

Lymphoma plasmablastic vs PCDLBL leg type

agree and would also include a myeloma in the differential

Agree with the differentials above. Needs IHC.

3 hours ago, Raul Perret said:

Lymphoma plasmablastic vs PCDLBL leg type

agree

Yes it’s a plasmacytic/plasmablastic family’s member, but I think this should be an extramedullary manifestation of plasmablastic myeloma rather then a plasmablastic lymphoma... or an extramedullary plasmocytoma.  

The tumour is negative for T and B cell markers .... Iskander Chaudhry 

CD138, Ki67, EBER?

...in keeping with plasmocytoma/myeloma (BCL2? CD138? CD38? CD56?)

plasmablastic lymphoma usually shows similar immunophenotype, but I don’t find the typical macronucleolus of plasmablastic ly. But these are spot observations of course.  

CD138, CD56, EBER, CD123??

Hi All 

The lesional cells are:

Positive for: CD45, CD43, CD138, CD56 (patchy), Kappa light chain restriction (mRNA)

Negative for: CD3, CD5, CD20, Pax5. 

Ki67 - high proliferation 

Your final diagnosis is: ........

Iskander

plasmablastic plasmacytoma/myeloma

Link without CPC and EBER I would be extremely cautious before rendering a definitive diagnosis

Agree

plasmablastic lymphoma vs. Plasmacytoma/myeloma

1 hour ago, Raul Perret said:

Link without CPC and EBER I would be extremely cautious before rendering a definitive diagnosis

Nice article, thanks Raul.

Thanks everyone!

Great discussion!! 

So patient has history of myeloma; HIV negative, EBER negative

Our final diagnosis was: 

Plasmablastic plasma cell myeloma

Beautiful case, thanks for sharing!!!